AYU (An International Quarterly Journal of Research in Ayurveda)

PHARMACOLOGICAL STUDY
Year
: 2015  |  Volume : 36  |  Issue : 3  |  Page : 335--340

Antihyperglycemic activity of Albizzia lebbeck bark extract in streptozotocin-nicotinamide induced type II diabetes mellitus rats


Priyank A Patel, Mihir P Parikh, Sarika Johari, Tejal R Gandhi 
 Department of Pharmacology, Anand Pharmacy College, Anand, Gujarat, India

Correspondence Address:
Mihir P Parikh
Asst. Prof., Department of Pharmacology, Anand Pharmacy College, Anand - 388 001, Gujarat
India

Introduction: Albizzia lebbeck (L.) Benth. (Family - Leguminosae) extract is a proven mast cell stabilizing agent. Mast cells are involved in the inflammatory processes leading to the diabetes mellitus. Aim: To evaluate the effect of A. lebbeck against experimentally induced type 2 diabetes mellitus in rats. Materials and Method: Female Sprague-Dawley rats were randomly allocated to six groups (n = 6). Diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg) given after 15 min of nicotinamide administration (110 mg/kg). Treatment with methanolic extract of A. lebbeck bark (MEAL) and metformin drug as standard was given for 21 days. Serum glucose (GLU) levels were measured on the 0 day and on 1st, 7th, 14th and 21st day after diabetes induction. After completion of study period, various biochemical parameters in serum such as - GLU, lipid profile, urea and creatinine were estimated. One-way analysis of variance followed with post-hoc Dunnett's test was used to analyse the data. Statistical significance for the values was set at P< 0.05. Results: MEAL significantly decreased the level of serum GLU, creatinine, urea, cholesterol, triglycerides, low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol and increased high-density lipoprotein levels. Conclusion: A. lebbeck bark extract showed antihyperglycaemic activity along with antihyperlipidemic effect.


How to cite this article:
Patel PA, Parikh MP, Johari S, Gandhi TR. Antihyperglycemic activity of Albizzia lebbeck bark extract in streptozotocin-nicotinamide induced type II diabetes mellitus rats.AYU 2015;36:335-340


How to cite this URL:
Patel PA, Parikh MP, Johari S, Gandhi TR. Antihyperglycemic activity of Albizzia lebbeck bark extract in streptozotocin-nicotinamide induced type II diabetes mellitus rats. AYU [serial online] 2015 [cited 2021 Jan 17 ];36:335-340
Available from: https://www.ayujournal.org/article.asp?issn=0974-8520;year=2015;volume=36;issue=3;spage=335;epage=340;aulast=Patel;type=0