Hematinic effect of fruits of <i>Opuntia elatior</i> Mill. on phenylhydrazine-induced anemia in rats :Sanjay P Chauhan, Navin R Sheth, Bhanubhai N Suhagia, AYU (An International Quarterly Journal of Research in Ayurveda)

PHARMACOLOGICAL STUDY
Year : 2015 | Volume : 36 | Issue : 2 | Page : 208--213

Hematinic effect of fruits of Opuntia elatior Mill. on phenylhydrazine-induced anemia in rats

Sanjay P Chauhan¹, Navin R Sheth², Bhanubhai N Suhagia¹
¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, India
² Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India

Correspondence Address:
Dr. Sanjay P Chauhan
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Dharmsinh Desai University, College Road, Nadiad - 387 001, Gujarat
India

Introduction: The fruits of Opuntia elatior Mill. are known as prickly pear and folkloric use as hematinic, anti-inflammatory and antiasthmatic action. Previously, the fruit juice of prickly pear was evaluated in reversed anemia induced by HgCl₂in a dose dependant manner and present study revealed about its effect in acute hemolytic anemia. Aim: To evaluate the hematinic activity of fruits of Opuntia elatior Mill. Materials and Methods: The hematinic activity of an orally administered fruit juice was studied on phenylhydrazine (PHZ)-induced anemic rats. The hematological parameters such as hemoglobin (Hb) content, red blood cell (RBC), packed cell volume (PCV), and reticulocyte count were analyzed as indices of anemia. Results: PHZ altered the hematological parameters by hemolysis characterized by a decrease in Hb content, total RBC counts and PCV (P < 0.001) on day 3. The Hb content (g%) was significantly increased (P < 0.05) at day 7 in 10 and 15 ml/kg fruit juice treated rats, which was a good improvement compared to the standard. Conclusion: The speedy and progressive recovery of anemic rats responding to treatment of the O. elatior Mill. fruits may be due to increased erythropoiesis and/or antioxidant property of betacyanin.

How to cite this article:
Chauhan SP, Sheth NR, Suhagia BN. Hematinic effect of fruits of Opuntia elatior Mill. on phenylhydrazine-induced anemia in rats.AYU 2015;36:208-213

How to cite this URL:
Chauhan SP, Sheth NR, Suhagia BN. Hematinic effect of fruits of Opuntia elatior Mill. on phenylhydrazine-induced anemia in rats. AYU [serial online] 2015 [cited 2021 Sep 17 ];36:208-213
Available from: https://www.ayujournal.org/article.asp?issn=0974-8520;year=2015;volume=36;issue=2;spage=208;epage=213;aulast=Chauhan;type=0