PHARMACOLOGICAL STUDY
Year : 2015 | Volume
: 36 | Issue : 2 | Page : 208--213
Hematinic effect of fruits of Opuntia elatior Mill. on phenylhydrazine-induced anemia in rats
Sanjay P Chauhan1, Navin R Sheth2, Bhanubhai N Suhagia1 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, India 2 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India
Correspondence Address:
Dr. Sanjay P Chauhan Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Dharmsinh Desai University, College Road, Nadiad - 387 001, Gujarat India
Introduction: The fruits of Opuntia elatior Mill. are known as prickly pear and folkloric use as hematinic, anti-inflammatory and antiasthmatic action. Previously, the fruit juice of prickly pear was evaluated in reversed anemia induced by HgCl2in a dose dependant manner and present study revealed about its effect in acute hemolytic anemia. Aim: To evaluate the hematinic activity of fruits of Opuntia elatior Mill. Materials and Methods: The hematinic activity of an orally administered fruit juice was studied on phenylhydrazine (PHZ)-induced anemic rats. The hematological parameters such as hemoglobin (Hb) content, red blood cell (RBC), packed cell volume (PCV), and reticulocyte count were analyzed as indices of anemia. Results: PHZ altered the hematological parameters by hemolysis characterized by a decrease in Hb content, total RBC counts and PCV (P < 0.001) on day 3. The Hb content (g%) was significantly increased (P < 0.05) at day 7 in 10 and 15 ml/kg fruit juice treated rats, which was a good improvement compared to the standard. Conclusion: The speedy and progressive recovery of anemic rats responding to treatment of the O. elatior Mill. fruits may be due to increased erythropoiesis and/or antioxidant property of betacyanin.
How to cite this article:
Chauhan SP, Sheth NR, Suhagia BN. Hematinic effect of fruits of Opuntia elatior Mill. on phenylhydrazine-induced anemia in rats.AYU 2015;36:208-213
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How to cite this URL:
Chauhan SP, Sheth NR, Suhagia BN. Hematinic effect of fruits of Opuntia elatior Mill. on phenylhydrazine-induced anemia in rats. AYU [serial online] 2015 [cited 2022 Aug 16 ];36:208-213
Available from: https://www.ayujournal.org/article.asp?issn=0974-8520;year=2015;volume=36;issue=2;spage=208;epage=213;aulast=Chauhan;type=0 |
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