AYU (An International Quarterly Journal of Research in Ayurveda)

PHARMACOLOGICAL STUDY
Year
: 2013  |  Volume : 34  |  Issue : 2  |  Page : 215--219

Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo


Sunil Kumar1, Gajendra Singh2, K. R. C. Reddy3 
1 Associate Professor Department of Sharira Rachana, National Institute of Ayurveda, Jaipur, India
2 Prof of Anatomy and Ex. Director, Institute of Medical Sciences, BHU, Varanasi, India
3 Associate Prof. Department of Rasashastra, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Correspondence Address:
Sunil Kumar
Associate Professor, Department of Sharira Rachana, National Institute of Ayurveda, Jaipur - 302 002, Rajasthan
India

Being an anti-mitotic and apoptosis inducing agent, Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups on intra-peritoneal injection (10 mg/kg) to pregnant mice on day 11 of gestation. Loss of body weight due to CP administration could be minimized by feeding Drakshavaleha (16 g/kg) orally to pregnant mice from day DQ0DQ to day DQ18DQ of their gestation. Recovery observed in terms of body weight of the pups was statistically significant (P < 0.001) in Drakshavaleha treated pups. Drakshavaleha also recovered the crown-rump length of the pups occurred due to CP administration. Growth retardation with decreased fetal weight was observed in all CP treated pups when compared with the controls.


How to cite this article:
Kumar S, Singh G, Reddy K. Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo.AYU 2013;34:215-219


How to cite this URL:
Kumar S, Singh G, Reddy K. Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo. AYU [serial online] 2013 [cited 2020 Dec 5 ];34:215-219
Available from: https://www.ayujournal.org/article.asp?issn=0974-8520;year=2013;volume=34;issue=2;spage=215;epage=219;aulast=Kumar;type=0