AYU (An International Quarterly Journal of Research in Ayurveda)

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 31  |  Issue : 2  |  Page : 153--158

Experimental evaluation of antidepressant effect of Vacha (Acorus calamus) in animal models of depression


AK Tripathi1, RH Singh2 
1 Department of Kayachikitsa, Government Ayurvedic College, Gurukul Kangri, Haridwar, India
2 Department of Kayachikitsa, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Correspondence Address:
A K Tripathi
Department of Kayachikitsa, Government Ayurvedic College, Gurukul Kangri, Haridwar
India

Depression is a common diagnosis throughout India. It is one of the major sequelae of modern lifestyle which is full of stress. Several drugs and therapies have been tried but a safe and effective treatment of depressive illness is yet not fully established. The main objective of this experimental study on animal models is to evaluate the antidepressant action of plant drug Vacha (Acorus calamus). The behavioral study was conducted and at the same time 5-HT receptor involvement was evaluated. The experimental study was done in rats to evaluate their Open Field Behavior (OFB), High Plus Maze (HPM) activity and 5-hydroxytryptamine (5-HT) receptor syndrome, before and after feeding Vacha. Concurrent Vacha administration in the depression model prevented the development of behavioral deficit in ambulation and rearing due to stress. Similarly, in High Plus Maze Test (HPMT), exploratory activity of rat was restored with Vacha administration. In adopted model of depression, when the animal was subjected to Vacha administration, the behavioural deficit was prevented very well as compared to stressed group. While eliciting the 5-HT syndrome, only two components out of five were influenced by Vacha, indicating that Vacha does not sensitize postsynaptic 5-HT1A receptors, which explains the behavioral deficit prevention in stressed rat group. Vacha definitely has antidepressant effects in animal model of depression.


How to cite this article:
Tripathi A K, Singh R H. Experimental evaluation of antidepressant effect of Vacha (Acorus calamus) in animal models of depression.AYU 2010;31:153-158


How to cite this URL:
Tripathi A K, Singh R H. Experimental evaluation of antidepressant effect of Vacha (Acorus calamus) in animal models of depression. AYU [serial online] 2010 [cited 2021 Apr 12 ];31:153-158
Available from: https://www.ayujournal.org/article.asp?issn=0974-8520;year=2010;volume=31;issue=2;spage=153;epage=158;aulast=Tripathi;type=0