AYU (An International Quarterly Journal of Research in Ayurveda)

RESEARCH ARTICLE
Year
: 2007  |  Volume : 28  |  Issue : 3  |  Page : 68--76

A Comparative Psycho-Neuro-Pharmacological Study on Guduchyadi Ghrita & Bhringarajadi Ghrita Rasayana


Devangi N Shukla1, Vinay Shukla2, B Ravishankar3, HM Chandola4 
1 Lecturer in Yogic Science, Morarji Desai Instt. Of Naturopathy & Yogic Science, Vadodara, Gujarat, India
2 Lecturer PGT- SFC-CELL, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
3 Head- Pharmacology Lab, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
4 Professor of Kayachikitsa, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
Devangi N Shukla
Lecturer in Yogic Science, Morarji Desai Instt. Of Naturopathy & Yogic Science, Vadodara, Gujarat
India

This study has been carried out to compare the Psycho-neuro-pharmacological basis for the use of Guduchyadi Ghrita and Bhringarajadi Ghrita. Guduchyadi Ghrita Rasayana consisting of Guduchi (Tinospora cordifolia Linn), Apamarga (Achyrenthus aspera Linn), Vidanga (Embelia ribes Burm. F.), Shankhapushpi (Convolvulus pluricaulis Chois), Vacha (Acorus calamus Linn), Haritaki (Terminalia chebula Retz), Kushtha (Saussurea lappa C.B.Clarke ) and Shatavari (Asparagus racemosus Willd), has proven mental health promoting, memory enhancing, anti-stress, anti- depressant properties that may slow down the Aging process by counteracting stress. Bhringarajadi Rasayana consisting of Bhringaraja (Eclipta alba Hassk.), Krishna Tila (Sesamum orientale Linn.), Amalaki (Embelica officinalis Gaertn.), Mishri (Sugar) with proven adaptogenic, antioxidant, free radicals scavenger, immuno-modulator properties play a major role in the management of Aging process. Both the formulations are supposed to possess CNS activity, Anti-stress, adaptogenic and other pharmacological activities. Based on this promise the test Ghrita had been studied on various experimental models such as Gross behaviour test, Anti depressant test, Anti-anxiety test and Antistress adaptogenic test on Swiss Albino Mice and Charles Foster strain albino rats of either sex. On Gross behaviour study, both the test drugs showed hypoactivity. In the Anti depressant activity, Guduchyadi Ghrita showed significant decrease in the Mice Behavioral DQdespairDQ test, moderate decrease in Mice immobility in Chronic fatigue syndrome test and produced potentiation of L dopa effects. Bhringarajadi Ghrita showed no discernible Anti depressant and Chronic fatigue syndrome test though moderate potentiation of L dopa effect was observed. Guduchyadi Ghrita also produces antianxiety activity and Adaptogenic activity. None of the formulation was able to reverse stress induced Hypothermia. Slightly higher decrease in stress induced ulceration was observed with Guduchyadi Ghrita, however Bhringarajadi Ghrita had no effect. No statistically significant effect observed on Haematological, Biochemical parameter and DHEA-S (Dehydroepiandrosterone Sulfate). Guduchayadi Ghrita showed marginal elevation of DHEA-S level.


How to cite this article:
Shukla DN, Shukla V, Ravishankar B, Chandola H M. A Comparative Psycho-Neuro-Pharmacological Study on Guduchyadi Ghrita & Bhringarajadi Ghrita Rasayana.AYU 2007;28:68-76


How to cite this URL:
Shukla DN, Shukla V, Ravishankar B, Chandola H M. A Comparative Psycho-Neuro-Pharmacological Study on Guduchyadi Ghrita & Bhringarajadi Ghrita Rasayana. AYU [serial online] 2007 [cited 2021 Apr 12 ];28:68-76
Available from: https://www.ayujournal.org/article.asp?issn=0974-8520;year=2007;volume=28;issue=3;spage=68;epage=76;aulast=Shukla;type=0