AYU (An International Quarterly Journal of Research in Ayurveda)

RESEARCH ARTICLE
Year
: 2006  |  Volume : 27  |  Issue : 3  |  Page : 55--62

A Toxicity Study of Makaradhwaja Prepared by Astasamskarita Parada


BJ Patgiri1, PK Prajapati2, B Ravishankar3 
1 Lecturer, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
2 Reader & Head, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
3 Head, Pharmacology laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
B J Patgiri
Lecturer, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar
India

Makaradhwaja is a well known Ayurvedic medicine prepared by Kupipakwa method. It is prepared by using shuddha Swarna (Gold), Astasamskarita Parada (Mercury) and shuddha Gandhaka (Sulphur) in the ratio of 1:8:16 as ingredients. The present study was under taken to ascertain the safety aspect of the drug through acute and chronic toxicity studies. Acute toxicity study was carried out in Swiss albino mice and chronic toxicity study was carried out in Charles Foster albino rats at different dose levels. The parameters studied were ponderal, haematological, biochemical and histopathological. in case of chronic toxicity study, mortality and behaviour change in acute toxicity. In acute toxicity study the test drug did not produce mortality up to the dose of 480 mg kg-1 (orally) in mice. The result or data obtained during the study indicate no significant changes observed in hematological, biochemical and histopathological parameters except of mild increase in blood sugar level and mild fatty changes in liver.


How to cite this article:
Patgiri B J, Prajapati P K, Ravishankar B. A Toxicity Study of Makaradhwaja Prepared by Astasamskarita Parada.AYU 2006;27:55-62


How to cite this URL:
Patgiri B J, Prajapati P K, Ravishankar B. A Toxicity Study of Makaradhwaja Prepared by Astasamskarita Parada. AYU [serial online] 2006 [cited 2021 Sep 28 ];27:55-62
Available from: https://www.ayujournal.org/article.asp?issn=0974-8520;year=2006;volume=27;issue=3;spage=55;epage=62;aulast=Patgiri;type=0