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   Table of Contents - Current issue
October-December 2021
Volume 42 | Issue 4
Page Nos. 149-175

Online since Wednesday, May 17, 2023

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Exploring the role of epigenetics in therapeutic and research – A boost to Ayurveda p. 149
Mandip Goyal
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Swasthya Assessment Scale (SAS)-Ayurveda based health assessment tool-insights on its development and validation p. 151
Jaiprakash Bholanath Ram, Babita Yadav, V Ashwathykutty, Sophia Jameela, Azeem Ahmad, Saket Ram Thrigulla, Sakshi Sharma, Rakesh K Rana, Richa Singhal, Bhogavalli Chandrasekhara Rao, N Srikanth, KS Dhiman
Introduction: Ayurveda has a unique way of understanding the body, health, and diseases. Various determinants, including biological, ecological, medical, psychological, sociocultural, spiritual, and metaphysical factors, which depend on each other, have their role in determining health in Ayurveda. Currently, no validated health assessment scale, based on the principles of Ayurveda is available. This article, for the first time, reports the development, validation, and reliability testing of the Swasthya assessment scale - a health assessment tool developed in Ayurveda. Materials and methods: A thorough literature search and expert consultations were done to draft the items encompassing the concept of health in Ayurveda. A group of experts assessed the content validity of the drafted items. Cognitive de-briefing and pretesting were performed to modify the language and the content again. Reliability testing was done with an inter-observer agreement in a sample of 183 individuals. Results: The content validity index for items and the scale-level content validity index (S-CVI) were calculated. S-CVI for scale was excellent, with 85% agreement. The S-CVI/universal agreement was 0.45, and S-CVI/Average was 0.95. In inter-rater reliability, the percentage agreement was 73.7%. Pearson correlation coefficient was 0.808 showing a strong correlation. Conclusion: Following appropriate validation, the scale can be widely used in clinical practice to assess the patient's health status, guide the treatment plans, and monitor the progress of the health. It can also be used as a sensitive tool in the research of Ayurveda to assess the changes in patients brought about by Ayurveda interventions.
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Management of Vandhyatva w.s.r. to thin Endometrium through Ayurveda- A single arm open labelled pilot clinical trial p. 156
Jalpa Deepak Rupareliya, Shilpa Donga, Abhay Jayprakash Gandhi
Background: The four essential factors of conception are Ritu (optimum period for conception), Kshetra (place of conception), Ambu (nutrition), and Beeja (healthy sperm and ovum). Kshetra denotes body as general and to be very specific, especially about the female reproductive system, it is Garbhashaya or the uterine cavity and function is Garbhadhana or conception. The endometrial factor is an important subset in infertility due to poor implantation. Aims: To evaluate the efficacy of Saubhagyanandana Ghrita Yonipichu (vaginal tampoon) and Jeevaniya Churna orally in the management of thin endometrium thickness and to evaluate its efficacy in the associate complains of menstrual abnormalities, i.e., irregularity of menstrual cycle, quantity, duration and pain. Materials and methods: It was a single-arm open labeled pilot clinical trial, a total of 15 female patients having endometrial thickness <7 mm on transvaginal sonography findings were included in the study. Each patient (n = 15) was given Saubhagyanandana Ghrita Yonipichu (10 mL for 6 days after cessation of menses, for 1 cycle) along with Jeevaniya Churna orally 10 g along with milk twice before meals for 30 days. Assessment of the study was done on Appelbaum's uterine scoring system for the reproduction (USSR) scoring pattern. Results: Results were analyzed by the paired' t-test for the objective parameters and Wilcoxon signed rank–sum test for the subjective parameters. A statistically highly significant difference (P < 0.001) was seen in endometrium thickness, layering, myometrial echogenicity, uterine Doppler flow, endometrial blood flow in zone 3, and total USSR score. Statistical significant difference (P < 0.05) was found in the menstrual abnormalities and a highly statistically significant difference (P < 0.001) was found in ovulation. One of the patients conceived after the treatment. Conclusion: Saubhagyanandana Ghrita Yonipichu (vaginal tampoon) and Jeevaniya Churna orally are effective in improving the thin endometrium.
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Agnikarma with Kshaudra (honey) along with adjuvant Ayurveda therapy in the management of trigger finger- A single case report p. 164
Riddhi Jitendrakumar Ganatra, Tukaram S Dudhamal
Trigger finger (TF) mechanical ailment results from a stenotic A1 pulley that has lost its gliding surface, producing friction and nodular change in the tendon. This results in pain and tenderness at the site of the A1 pulley which further progresses into catching and then locking of the finger. A definite cure of TF in the current mainstream is the surgical release of the A1 pulley. A 71-year-old male patient with a TF presented with pain, swelling, and locking of the left hand's middle finger. The patient was considered as suffering from Snayugata Vata as an Ayurveda diagnosis and treated with Kshaudra Agnikarma (therapeutic burn with honey) on daily basis at the morning for 30 days and Bandhana (bandages) for 2 months along with Dashmoola Kwatha orally 20 mL empty stomach twice a day and Haritaki Churna 5 g at night with lukewarm water orally for 2 months. The patient was clinically assessed and Green's Severity Scores of TF showed remarkable improvement after the completion of treatment. This single case report demonstrates that the case of TF can be successfully managed with Kshaudra Agnikarma – A minimally invasive nonsurgical therapeutic intervention using Ayurveda principles.
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An experimental study to evaluate Gunasankarya (combination of properties) p. 169
Jiji U Nair, Hitesh A Vyas, Mukesh B Nariya
Introduction: Gunasankarya implies the combination or admixture of different Guna (properties) in a Dravya (substance). Every Dravya in this world is composed of different Guna varying in their quantity and potency. The final resultant action of the Dravya depends on the combination of Guna and their interaction with each other. Aim: The present study was aimed to explain the manifestation of Karma (action) of a Dravya through its Guna (properties) and to evaluate the effect of the combination of Sheeta Guna (cool property) with different other Guna on digestion and metabolism in an animal model. Materials and methods: The test drugs Usheera (Vetiveria zizanioides Linn.) and Bala (Sida cordifolia Linn.) were dried and powdered. A total of 18 adult healthy male and female Wistar strain albino rats were grouped randomly into three groups out of which the first was the control group and administered with distilled water. The second and third groups were fed with powder of Usheera and Bala, respectively, in the suspended form in distilled water. Test drugs were administered daily for 12 consecutive days. During the experimental phase, relative food intake, relative water intake, relative urine output, relative stool output, and food conversion ratio were recorded on the 3rd, 6th, 9th, and 12th day among which the 3rd day was considered as the initial day for the assessment, whereas body weight was measured from the 1st day of the study. Throughout the study, the main focus was on how these parameters change in Usheera and Bala-treated rats which are having different combinations of Guna with reference to the control group. Results: Both Usheera and Bala groups showed a nonsignificant increase in relative food and water intake, nonsignificant increase in relative urine output, significant decrease in relative stool output, and significant increase in food conversion ratio. Body weight was nonsignificantly increased in Usheera group, whereas it was nonsignificantly decreased in Bala group. This study aimed to show how the Guna are interacting and resulting in Karma either by dominating or suppressing or giving a combined effect of Guna. This study provides initial data regarding the concept of Gunasankarya (combination of properties). Conclusion: The study concludes that all the Guna in a Dravya interact and exhibit their resultant action, i.e., Karma based on Gunasankarya, with emphasis on example of assessment of the effects of Sheeta Guna Dravya, namely, Usheera and Bala on physiological parameters (digestion and metabolism) have been assessed experimentally in animal models to evaluation of the combination of Guna.
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Marijauna (Cannabis sativa L.) and roles against monkeypox p. 175
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
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