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ORIGINAL ARTICLE
Year : 2016  |  Volume : 37  |  Issue : 2  |  Page : 145-150

Evaluation of glucose utilization capacity of bioactivity-guided fractions of Barleria prionitis Linn and Hyptis suaveolens (L.) Poit in isolated rat hemidiaphragm


1 Department of Pharmacognosy and Phytochemistry, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India
2 Department of Pharmacy, Faculty, University College of Chemical Technology, Osmania University, Hyderabad, Telangana, India

Correspondence Address:
Sama Venkatesh
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad - 500 028, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ayu.AYU_198_15

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Introduction: Diabetes mellitus (DM) is a chronic disease characterized by high blood glucose levels due to absolute or relative circulating insulin levels. Plants represent a major potential source of drugs for treating diabetes. The study of plants having antidiabetic activity may give a new approach in the treatment of DM. Aim: This study was aimed to investigate the glucose utilization capacity of bioactivity-guided fractions of Barleria prionitis and Hyptis suaveolens. Materials and Methods: The dried coarse powdered plant material was extracted in aqueous ethanol by cold maceration; further, ethanolic extracts were fractionated using solvents of varying polarity and were investigated in isolated rat hemidiaphragm using 0.1* and 0.2* concentrations of plant extracts. Results: The tested fractions of both plants showed significant and dose-dependent increased glucose uptake capacity and was found to be maximum with petroleum ether and aqueous ethanolic extracts of both plants; 0.2* concentration of both plant extracts is superior in activity when compared to 0.1* of the test extracts. H. suaveolens has produced more glucose utilization capacity when compared to B. prionitis. Conclusion: The activity of H. suaveolens is comparable to standard insulin (P < 0.01). Both the plant materials have some extra pancreatic mechanism like glucose uptake by peripheral tissue.


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