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PHARMACOLOGICAL STUDY
Year : 2015  |  Volume : 36  |  Issue : 3  |  Page : 335-340

Antihyperglycemic activity of Albizzia lebbeck bark extract in streptozotocin-nicotinamide induced type II diabetes mellitus rats


Department of Pharmacology, Anand Pharmacy College, Anand, Gujarat, India

Correspondence Address:
Mihir P Parikh
Asst. Prof., Department of Pharmacology, Anand Pharmacy College, Anand - 388 001, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.182752

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Introduction: Albizzia lebbeck (L.) Benth. (Family - Leguminosae) extract is a proven mast cell stabilizing agent. Mast cells are involved in the inflammatory processes leading to the diabetes mellitus. Aim: To evaluate the effect of A. lebbeck against experimentally induced type 2 diabetes mellitus in rats. Materials and Method: Female Sprague-Dawley rats were randomly allocated to six groups (n = 6). Diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg) given after 15 min of nicotinamide administration (110 mg/kg). Treatment with methanolic extract of A. lebbeck bark (MEAL) and metformin drug as standard was given for 21 days. Serum glucose (GLU) levels were measured on the 0 day and on 1st, 7th, 14th and 21st day after diabetes induction. After completion of study period, various biochemical parameters in serum such as - GLU, lipid profile, urea and creatinine were estimated. One-way analysis of variance followed with post-hoc Dunnett's test was used to analyse the data. Statistical significance for the values was set at P< 0.05. Results: MEAL significantly decreased the level of serum GLU, creatinine, urea, cholesterol, triglycerides, low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol and increased high-density lipoprotein levels. Conclusion: A. lebbeck bark extract showed antihyperglycaemic activity along with antihyperlipidemic effect.


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