| PHARMACEUTICAL STANDARDIZATION |
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| Year : 2015 | Volume
: 36
| Issue : 3 | Page : 318-322 |
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A contemporary approach on design, development, and evaluation of Ayurvedic formulation - Triphala Guggulu
Ganesh Muguli1, Vishakante D Gowda2, Vishnu Dutta2, Atul N Jadhav1, Bibhilesh B Mendhe1, Rangesh Paramesh1, UV Babu1
1 Research and Development Center, The Himalaya Drug Company, Bengaluru, Karnataka, India
2 Department of Pharmaceutics, JSS College of Pharmacy, Mysore, Karnataka, India
Correspondence Address:
Ganesh Muguli
Research and Development Center, The Himalaya Drug Company, Makali, Bengaluru, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8520.182748
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Introduction: Ayurvedic texts describe many formulations for different ailments. Triphala Guggulu (TG) is reputed for treating inflammatory conditions. These formulations have been considered complementary medicine or alternative to conventional medicines across the globe. These complex polyherbal formulations need science-based approach toward manufacturing process and chemical standardization. Aim: To evaluate TG tablets to meet modern pharmaceutical approaches and also standardization processes. Materials and Methods: Shodhana of Guggulu was performed using Triphala Kwatha (decoction) as mentioned in ayurvedic texts. This processed material was dried using spray drying technique, blended with other herbal powders as per formula and using suitable excipients was incorporated for compressing into tablets. Excipients and their concentrations were evaluated for various micromeritic properties and the formula that met the requirements was compressed. Results: The angle of repose was considered fair with a range of 25–30, Carr's index at a range between 17 and 30, and Hausner ratio of 1.21:1.44, which was well within the limits as per the United States Pharmacopeia (USP) and among the three blends tested, blend Triphala Guggulu formulation-3 was found most suitable for tablets compression. Physical properties were well within the limits as per the USP and disintegration time was within 30 min. Conclusion: Modern pharmaceutical processing can very well be adapted for Guggulu preparations. |
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