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PHARMACOLOGICAL STUDY
Year : 2015  |  Volume : 36  |  Issue : 1  |  Page : 101-106

Protective effect of Agave americana Linn. leaf extract in acetic acid-induced ulcerative colitis in rats


1 Department of Pharmacology, Al-Maarefa Colleges for Science and Technology, Riyadh, Saudi Arabia
2 Department of Pharmacology, SETs College of Pharmacy, Dharwad, India
3 Department of Pharmacology, Sarada Vilas College of Pharmacy, Mysuru, India
4 Department of Pharmacology, East West College of Pharmacy, Bengaluru, Karnataka, India

Correspondence Address:
Basheerahmed A.A Mannasaheb
Department of Pharmacology, Al-Maarefa College for Science and Technology, Riyadh
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.168998

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Introduction: Natural plants always provide core compounds for new drug development. In the present life and food style, inflammatory bowel disease has become common and needs a lead compound for its drug development.Aim: To evaluate the effect of Agave americana Linn. leaf extract in acetic acid-induced ulcerative colitis in rats based on its traditional anti-inflammatory use. Materials and Methods: Male Wistar rats were pretreated with A. americana leaf extract in the dose of 200 and 400 mg/kg p.o. daily for 7 days. On 8th day, 2 ml of 4% v/v acetic acid in saline was instilled into rats' rectum. Prednisolone was used as standard drug and it was administered on the day of acetic acid instillation and continued for 3 days. Extract treatment was continued till 11th day. Body weight, ulcer score, colonic muscle contraction, antioxidant activity and histopathology were studied. Statistical analysis was performed using Parametric one-way analysis of variance followed by Tukey's posttest. Results: A. americana have retained total body weight significantly (P < 0.01) and decreased colon weight/length ratio. Extract have shown a significant decrease (P < 0.001) in ulcer scores, myeloperoxidase, lipid peroxidase activity. Further, extract have shown significant improvement in colonic muscle contraction, histopathology of colon etc., which is comparable with standard drug. Conclusion: A. americana possess protective effect against acetic acid-induced colitis in rats.


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