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Year : 2014  |  Volume : 35  |  Issue : 4  |  Page : 438-441

Bioavailability study of calcium sandoz-250 by atomic absorption spectroscopy in albino rats

1 Department of Pharmaceutical Analysis, C.U. Shah College of Pharmacy and Research, Wadhwan, Gujarat, India
2 Department of Pharmaceutical Analysis, J.S.S. College of Pharmacy, Ooty, Tamil Nadu, India
3 Department of Pharmaceutics, C.U. Shah College of Pharmacy and Research, Wadhwan, Gujarat, India

Correspondence Address:
Bimalkumar N Patel
68, Kunta Park Society, Near Taramani Township, New 80 Feet Road, Wadhwan City, Surendranagar - 363 035, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-8520.159020

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Background: Calcium sandoz-250 is an Ayurvedic calcium supplement, containing Khatika Churna. Bioavailability study of the formulation is essential for estimation of peak plasma concentration (Cmax ), time to Cmax and rate of absorption. Aim: To evaluate the absorption parameters of calcium sandoz-250 in albino rats by atomic absorption spectroscopic (AAS) method. Materials and Methods: Study was carried out as a single dose, open-label, randomized study. Estimation of calcium was carried out by AAS, after validating the method for a few parameters for the estimation. Pharmacokinetic parameters such as Cmax , time to peak concentration (Tmax ), area under the plasma concentration - time curve were calculated for calcium on administration of calcium sandoz-250. Results: Linearity curve was plotted for 0.5-2.5 ppm, given R2 value 0.9975. The Cmax , i.e. Cmax after administration of calcium sandoz-250 was 0.793 mg/ml at 90 min (Tmax ). Measurable calcium-blood levels were noticed in all subjects up to 3.0 h after administration of calcium sandoz-250. Conclusion: Calcium sandoz-250, consisting of Khatika Churna, increases the blood calcium level in albino rats.

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