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| CLINICAL RESEARCH |
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| Year : 2014 | Volume
: 35
| Issue : 2 | Page : 148-151 |
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Effect of Anuvasana Basti with Ksheerabala Taila in Sandhigata Vata (Osteoarthritis)
Pradeep L Grampurohit1, Niranjan Rao2, Shivakumar S Harti3
1 Department of Panchakarma, K.L.E. University's Shri B.M. Kankanawadi Ayurved Mahavidyalaya, Belgaum, India
2 Department of Panchakarma, S.D.M College of Ayurveda, Udupi, India
3 Department of Swasthavritta, K.L.E. University's Shri B.M. Kankanawadi Ayurved Mahavidyalaya, Belgaum, Karnataka, India
| Date of Web Publication | 5-Dec-2014 |
Correspondence Address:
Pradeep L Grampurohit
Assistant Professor, Department of Panchakarma, KLE University's Shri B.M.K. Ayurved Mahavidyalaya, Belgaum - 530 003, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8520.146225
 Abstract | | |
Background: Osteoarthritis (OA) is the most common joint disorder. In Ayurveda the disease Sandhigata Vata resembles with OA, which is described under Vatavyadhi. Treatment provides symptomatic relief, but the underlying pathology remains unchecked due to the absence of effective drugs. In the management of Sandhigata Vata, all the Acharyas have described the employment of Bahya Snehan, Swedana, Abhyantara Tikta Snehapana, Basti treatment and Guggulu Prayoga. Aim: To evaluate the effect of Ksheerbala Taila Anuvasana Basti in Sandhigata Vata Materials and Methods: In the present study, 30 patients of Sandhigata Vata were given Anuvasana Basti with Ksheerabala Taila. Subjective assessment of pain by visual analog scale and swelling, tenderness, crepitus and walking velocity were graded according to their severity. Results: Significant results (P < 0.05) were found in all the cardinal symptoms - Pain (Sandhiruja), Swelling (Shotha), tenderness, crepitus and walking velocity. Radiological findings showed no significant changes. Conclusion: Anuvasana Basti with Ksheerabala Taila was significant in the subjective symptoms of Sandhigata Vata. Keywords: Anuvasana Basti, Ksheerabala Taila, Sandhivata
How to cite this article:
Grampurohit PL, Rao N, Harti SS. Effect of Anuvasana Basti with Ksheerabala Taila in Sandhigata Vata (Osteoarthritis). AYU 2014;35:148-51 |
| Introduction | |  |
Osteoarthritis (OA) is the second most common rheumatologic problem in India and has a prevalence rate of 22-39%. [1] It is characterized primarily by articular cartilage degeneration and a secondary periarticular bone response. [2],[3] World-wide prevalence rate of OA is 20% for men, 41% for women and it causes pain or dysfunction in 20% of the elderly respectively. [4] Relieving pain stiffness and improving physical functions are the important goals of the present day therapy. [5],[6] Although OA itself is not a life-threatening disease, Quality of life can significantly deteriorate with pain and loss of mobility causing dependence and disability. [7] In Ayurveda, the disease Sandhigata Vata resembles with OA, which is described under Vatavyadhi. [8]
Anuvasana Basti is the treatment of choice in Vatavyadhi. [9] Ksheerabala Taila is one of the most popular oil preparations in Ayurveda and recognized as a very effective remedy for neurological disorders such as facial paralysis, sciatica, hemiplegia, paraplegia, poliomyelitis and other such conditions. The similar preparation has been mentioned by almost all ancient Ayurvedic texts but with different names. Charaka mentioned as Shatasahasra Paka Bala Taila.[10] Sushruta mentioned as Shata Paka Bala Taila[11] and Ashtanga Hridaya mentioned as Shata Paka-Sahasra Paka Bala Taila.[12] The ingredients of this preparation are Ksheera (Cow's milk), Bala (Sida cordifolia Linn.) and Tila Taila (Sesame oil). Ksheerabala Taila is used for the purpose of Anuvasana Basti. S. cordifolia has been reported to possess analgesic, anti-inflammatory as well as hepato-protective activity. [13],[14],[15] Charaka advises Anuvasana Basti to be administered in Vatavyadhis.[16] The objective of the present study is to evaluate the effect of Ksheerabala-Taila Anuvasana Basti in Sandhigata Vata.
| Materials and Methods | | |
A total of 30 subjects with OA knees were recruited for the study among which 25 subjects (16 female and 9 male) completed the whole course and 5 dropped out. The study was approved by the Institutional Review Board (IRB) and Institutional Ethics Committee (IEC) (Ref No.: SDMAMC/03-04/D-1059). Signed informed consent was obtained from all the participants.
Inclusion criteria
- Persistent pain for 3 months prior to recruitment
- Moderate-to-severe pain on walking
- Fully ambulant, literate and willing to participate in the study.
Exclusion criteria
- Acute knee pain
- Secondary OA due to rheumatoid arthritis, gout, septic arthritis, tuberculosis, tumor, trauma, or hemophilia
- Major medical or psychiatric disorders.
Design
It is a single group clinical study with pre-test and post-test design. A special proforma was prepared with all points of history taking, examination, laboratory and roentgen-logic investigations to confirm the diagnosis as mentioned in our classics and allied sciences.
Intervention
The patients were treated with Anuavasana Basti with Ksheerabala Taila 120 ml for 10 days. 5 g of Saindhava was added to Ksheerabala Taila while administering Basti. The Basti was given daily between 2 pm and 3 pm in the afternoon after food.
The subjects were not given any other medications or topical treatments during the trial. The patients were assessed pre-test, post-test and after the follow-up period of 20 days.
Basti Pratyagamana Laxanas were all noted and No adverse events were noted during the trial.
Criteria for assessment
Subjective parameters
I Visual Analog Scale (VAS) was used for assessing pain.
II Swelling
Grade 0 - No swelling
Grade 1 - Slight swelling
Grade 2 - Moderate swelling
Grade 3 - Severe swelling
III Tenderness was evaluated on the basis of standard criteria of "Ritchie Articular Index."
Grade 0 - Normal - Absent or no tender
Grade 1 - Mild - Tender
Grade 2 - Moderate - Tenderness and wincing
Grade 3 - Severe - Tenderness, wincing and withdrawal
IV Crepitus
Grade 0 - Normal - No crepitus
Grade 1 - Mild - Crepitus complained by patient but not felt on examination
Grade 2 - Moderate - Crepitus felt on examination
Grade 3 - Severe - Crepitus felt and heard on examination
V Walking velocity
Grade 0 - Normal - 20 min in 20 s
Grade 1 - Mild - 20 min in 30 s
Grade 2 - Moderate - 20 min in 40 s
Grade 3 - Severe - 20 min in 50 s
Objective parameters
Radiological findings
The Kellgren-Lawrence index was used to assess the changes in radiological finding.
Grade 1 - Doubtful narrowing of joint space and possible osteophytic lipping
Grade 2 - Definite osteophytes, definite narrowing of joint space
Grade 3 - Moderate multiple osteophytes, definite narrowing of joints space, some sclerosis and possible deformity of bone contour
Grade 4 - Large osteophytes, marked narrowing of joint space, severe sclerosis and definite deformity of bone contour
Overall effect of therapy
No improvement: 0-25%, mild improvement: >25-50%, moderate improvement: >50-75%, marked improvement: >75-<100% and complete remission: 100%.
| Observations | | |
In present study, 48% of the patients gave a history of pain in both knee joints, while 40% complained of pain in right knee joint, only 12% in left knee joint. 84% of the patients were found were having Santarpanottha and 16% were Apatarpanottha Vyadhi. Majority of the patients (64%) had the history of complaints between 1 and 5 years, followed by more than 5 years (20%) and less than 1 year (16%). Maximum (52%) patients had Kellegren Roentgenologic evidence of OA in Grade 2, followed by Grade 3 (40%) and Grade 1 (8%). There were no patients in Grade 4.
Most of the patients had Basti Pratyagama Kala in 6-9 hrs (40%), followed by 3-6 hrs (32%), less than 3 hrs (16%) and more than 9 h (12%). The maximum Basti retension time noted was 9.53 h and minimum was 1.43 h. The mean Basti retention time was 4.56 h.
| Results | | |
There was significant reduction (P < 0.05) in subjective symptoms such as pain, swelling, tenderness, crepitus and walking velocity. There was insignificant change in radiological findings [Table 1]. In the overall effect of the therapy, 56% (14) had mild improvement, 48% (08) had moderate improvement and 12% (03) had no improvement.
| Discussion | | |
Sandhigata Vata is a disorder dominated by pain affecting the Sandhi (joint). It is caused by morbid Vata Dosha. Kapha Dosha may also be involved in the clinical presentation. The vitiated Dosha or Doshas afflict the Mamsa, Asthi and Snayu. It is more evident in Asthi Dhatu with which Vayu has Ashraya-Ashrayee Bhava Sambhanda.
As per age-wise distribution, maximum numbers of patients (60%) in this study were in the age group of 51-60 years. This is the age wherein Hani (deterioration) of Dhatus starts. [17] In this study, maximum numbers of patients (64%) were females. Sex hormones have long been considered a possible factor in the systemic predisposition to OA, especially in women. [18],[19],[20]
Nearly 16% of patients had chronicity below 1 year, whereas 64% of patients were between 1 and 5 years and remaining 20% of patients were more than 5 years.
Significant results (P < 0.05) were found in all the cardinal symptoms - Sandhiruja (pain), Shotha (swelling), tenderness and crepitus. There was significant improvement in walking velocity. This proves that Anuvasana Basti with Ksheerabala Taila is effective in Sandhigata Vata. Pain and crepitus are mainly due to Vata Dosha and above data proves that Anuvasana Basti with Ksheerabala Taila controls Vata Dosha and relieves these symptoms.
Probable mode of action of Basti
Basti Chikitsa is the prime treatment modality of Ayurveda. It is also considered as Ardha Chikitsa (half treatment). Sneha or Anuvasana Basti (unctuous enema) promotes Bala (strength) of the person who is emaciated and debilitated. About the possibility of the absorption of Basti Dravyas (drugs) from the colon, some are of the opinion that substances other than water, salt, etc., are not absorbed from the large gut; but this is physiological phenomenon occurring in day-to-day life, while the colon mucosa under the effect of the medication can be rendered to absorb the unusual substance also from the large gut. Favoring this view modern medical science is suggestive of some of the nutrient enemas meant for the nutrition of the body, where absorption of carbohydrate, fat and protein is mentioned. [21]
Observation of modern medical science that administration of sodium chloride improves fat absorption [21] is curiously coinciding with the usage of salt designed by Ayurvedic medical authorities in Sadyo-Snehana[22] and in many Basti Dravya preparations along with the different Sneha Dravyas. Charaka narrates the role played by Lavana along with the Sneha by the words "Lavanopitaha Snehana Snehayantyachiratnaram.0" [23] Charaka while assessing the Anuvasana Basti records the digestion of Sneha by the words "Sneham Pachati Pavakah" [24] and after digestion Dravyas can be absorbed to cause the affect on the body.
| Conclusion | | |
Anuvasana Basti with Ksheerabala Taila was significant in reducing the subjective symptoms of Sandhigata Vata. There was no significant improvement in radiological findings.
| References | | |
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| 9. | Agnivesha, Charaka, Dridhabala, Charaka Samhita, Chikitsa Sthana, Vatavyadhi Chikitsa Adhyaya, 28/77, edited by Tripathi B, Deshpande PJ, reprint ed. Chaukambha Sanskrit Pratishtan, Varanasi, 2003; 951. |
| 10. | Ibidem. Charaka Samhita, Chikitsa Sthana, Vatavyadhi Chikitsa Adhyaya, 29/119-120; 1002. |
| 11. | Sushruta, Sushruta Samhita, Chikitsa Sthana, Mudhagarbha Chikitsa Adhyaya 15/40-43, edited by Ambikadatta Shastri, 14 th ed. Chaukambha Sanksrit Prathishtan, Varanasi, 2003; 76. |
| 12. | Vagbhata, Ashtanga Hridaya, Chikitsa Sthana, Vatashonita Chikitsa Adhyaya, 22/45-46, edited by Gupta A, Upadhyaya Y, reprint ed. Chaukambha Sanksrit Prathishtan, Varanasi, 2005; 826. |
| 13. | Kanth VR, Diwan PV. Analgesic, antiinflammatory and hypoglycaemic activities of Sida cordifolia. Phytother Res 1999;13:75-7. |
| 14. | Rao KS, Mishra SH. Antihepatotoxic activity of Sida cordifolia whole plant. Fitoterapia 1998;LXIX: 20-3. |
| 15. | Sutradhar RK, Rahman MA, Ahmad MU, Datta BK, Bachar SC, Saha A. Analgesic and antiinflammatory activities of Sida cordifolia Linn. Indian J Pharmacol 2006;38:207-8. |
| 16. | Agnivesha, Charaka, Dridhabala, Charaka Samhita, Siddhi Sthana, Kalpanasiddhiradhyaya, 1/25, edited by Tripathi B, Deshpande PJ, reprint ed. Chaukambha Sanskrit Pratishtan, Varanasi, 2003; 1165. |
| 17. | Sushruta, Sushruta Samhita, Sutra Sthana, Vyadhisamuddeshiya Adhyaya, 24/8, edited by Ambikadatta Shastri, 14 th ed. Chaukambha Sanksrit Prathishtan, Varanasi, 2003; 101. |
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| 19. | Lindsay R Estrogen deficiency. In: Riggs BL, Melton, editors. Osteoporosis: etiology, Diagnosis and Management. 2 nd ed. Philadelphia: Lippincott-Raven; 1995. pp. 133-60. |
| 20. | Kritz-Silverstein D, Barrett-Connor E. Early menopause, number of reproductive years, and bone mineral density in postmenopausal women. Am J Public Health 1993;83:983-8. |
| 21. | Chattergee CC. Human Physiology (Vol. 1). 10 th ed. Calcutta: Medical Allied Agency; 1985. pp. 6-36, 2-35. |
| 22. | Vagbhata. Ashtanga Hridaya, Sutra Sthana, Snehavidhi Adhyaya, 16/43, edited by Late. Dr. Anna Moreswara Kunte, ed. Chaukhambha Publication, Varanasi, 1998; 536. |
| 23. | Agnivesha, Charaka, Dridhabala, Charaka Samhita, Sutra Sthana, Snehadhyaya, 13/98, edited by Tripathi B, Deshpande PJ, reprint ed. Chaukambha Sanskrit Pratishtan, Varanasi, 2003; 284. |
| 24. | Ibidem. Charaka Samhita, Siddhi Sthana, Kalpanasiddhir Adhyaya, 1/47; 889 |
[Table 1]
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