| PHARMACOLOGICAL STUDY |
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| Year : 2013 | Volume
: 34
| Issue : 2 | Page : 215-219 |
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Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo
Sunil Kumar1, Gajendra Singh2, K. R. C. Reddy3
1 Associate Professor Department of Sharira Rachana, National Institute of Ayurveda, Jaipur, India
2 Prof of Anatomy and Ex. Director, Institute of Medical Sciences, BHU, Varanasi, India
3 Associate Prof. Department of Rasashastra, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Correspondence Address:
Sunil Kumar
Associate Professor, Department of Sharira Rachana, National Institute of Ayurveda, Jaipur - 302 002, Rajasthan
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8520.119686
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Being an anti-mitotic and apoptosis inducing agent, Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups on intra-peritoneal injection (10 mg/kg) to pregnant mice on day 11 of gestation. Loss of body weight due to CP administration could be minimized by feeding Drakshavaleha (16 g/kg) orally to pregnant mice from day "0" to day "18" of their gestation. Recovery observed in terms of body weight of the pups was statistically significant (P < 0.001) in Drakshavaleha treated pups. Drakshavaleha also recovered the crown-rump length of the pups occurred due to CP administration. Growth retardation with decreased fetal weight was observed in all CP treated pups when compared with the controls. |
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