Evaluation of anti-urolithiatic activity of Pashanabhedadi Ghrita against experimentally induced renal calculi in rats

Sanjay Kumar Gupta; Madhav Singh Baghel; Chaturbhuja Bhuyan; B Ravishankar; BK Ashok; Panchakshari D Patil

doi:10.4103/0974-8520.108860

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PHARMACOLOGICAL STUDY

Year : 2012 | Volume : 33 | Issue : 3 | Page : 429-434

Evaluation of anti-urolithiatic activity of Pashanabhedadi Ghrita against experimentally induced renal calculi in rats

Sanjay Kumar Gupta¹, Madhav Singh Baghel², Chaturbhuja Bhuyan³, B Ravishankar⁴, BK Ashok⁵, Panchakshari D Patil⁶
¹ Associate Professor and I/C Head, Department of Shalya Tantra, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
² Director, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
³ Director, Centre for Care of Ano-Rectal Research by Indian System of Medicine and Allied Science, Bhubaneshwar, Orissa, India
⁴ Director, Research and Development, SDM Ayurveda College, Kuthpady, Udupi, Karnataka, India
⁵ Research Associate, Drug Discovery Group, Research and Development Himalaya Health Care, Bengaluru, Karnataka, India
⁶ Senior Research Fellow, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

Correspondence Address:
Sanjay Kumar Gupta
Department of Shalya Tantra, IPGT and RA, Gujarat Ayurved University, Jamnagar- 361 008, Gujarat
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0974-8520.108860

Population in an industrialized world is afflicted by urinary stone disease. Kidney stones are common in all kinds of urolithiasis. One distinguished formulation mentioned by Sushruta for management of Ashmari (urolithiasis) is Pashanabhedadi Ghrita (PBG), which is in clinical practice since centuries. Validation of drug is the requirement of time through the experimental study. In this study, trial of PBG has been made against ammonium oxalate rich diet and gentamicin injection induced renal calculi in albino rats. The calculi were induced by gentamicin injection and ammonium oxalate rich diet. Test drug was administered concomitantly in the dose of 900 mg/kg for 15 consecutive days. Rats were sacrificed on the 16 ^th day. Parameters like kidney weight, serum biochemical, kidney tissue and histopathology of kidney were studied. Concomitant treatment of PBG attenuates blood biochemical parameters non-significantly, where as it significantly attenuated lipid peroxidation and enhanced glutathione and glutathione peroxidase activities. It also decreased crystal deposition markedly into the renal tubules in number as well as size and prevented damage to the renal tubules. The findings showed that PBG is having significant anti-urolithiatic activities against ammonium oxalate rich diet plus gentamicine injection induced urolithiasis in rats.

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