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PHARMACOLOGICAL STUDY
Year : 2012  |  Volume : 33  |  Issue : 3  |  Page : 418-422

Evaluation of subchronic genotoxic potential of Swarna Makshika Bhasma


1 Reader, Department of Rasa Shastra and Bhaishajya Kalpana, Ashwini Ayurvedic Medical College and Research Centre, Tumkur, Karnataka, India
2 Associate Professor, Department of Rasa Shastra and Bhaishjya Kalpana including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
3 Lecturer, Department of Pharmacology, SSR College of Pharmacy, Silvasa, UT of D and NH, India
4 Director, Research and Developement, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka, India
5 PhD Scholar, Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

Correspondence Address:
Pavan B Savalgi
Department of RS and BK, Ashwini Ayurvedic Medical College and Research Centre, Tumkur - 572 105, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.108858

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Extremely diminutive published information is available on the mutagenic activity of Ayurvedic Bhasmas. Genotoxicity of few Bhasmas were reported on single maximum dose, but no reference is available on the sub-chronic level. Hence the present study was carried to generate and evaluate genotoxic potentials of Swarna Makshika Bhasma (mineral preparation) administered at therapeutic dose for 14 days. Chromosomal aberrations and abnormal sperm assay parameters were taken in this study. Cyclophosphamide (CP) was taken as positive group and results were compared. The results revealed a lack of generation of structural deformity in above parameters by tested drugs compared to CP treated group. Observed data indicate that the Bhasmas tested were non-genotoxic under the experimental conditions.


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