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| CLINICAL RESEARCH |
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| Year : 2010 | Volume
: 31
| Issue : 4 | Page : 478-481 |
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Effects of Ayurvedic treatment on forty-three patients of ulcerative colitis
Manish V Patel1, Kalapi B Patel2, SN Gupta3
1 Lecturer, Department of Kayachikitsa, J. S. Ayurved College, Nadiad, Gujarat, India
2 Reader, Department of Panchakarma, J. S. Ayurved College, Nadiad, Gujarat, India
3 Professor and Head, Department of Kayachikitsa, J. S. Ayurved College, Nadiad, Gujarat, India
| Date of Web Publication | 13-Jun-2011 |
Correspondence Address:
Manish V Patel
Doctors' Staff Quarters, J. S. Ayurved Mahavidyalay, College Road, Nadiad - 387 001
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-8520.82046
 Abstract | | |
Ulcerative colitis is a chronic idiopathic inflammatory bowel disease with a relapsing nature. It is a very challenging disease affecting a patient during the most active period of his life i.e. 20 to 40 years of age. The main features are ano-rectal bleeding with increased frequency of bowel evacuation, general debility and with abnormal structural pathology in the descending colon, particularly sigmoid colon. In modern medical science, there is no permanent curative and safe treatment for this disease. This study can be helpful for reducing the need of steroids and surgical processes in the patients of ulcerative colitis. A clinical study of 43 patients of ulcerative colitis has been conducted at the O.P.D. (outdoor patient department) and I.P.D. (indoor patient department) of the P D Patel Ayurveda Hospital, Nadiad. They were given Udumbara kvatha basti with oral Ayurveda medicaments including Kutaj ghan vati, Udumbara kvatha, and combination of Musta, Nagakesara, Lodhra, Mukta panchamrut rasa for a one-month period. Results were analyzed statistically by using the 't' test. In this study, it was observed that the symptoms and signs, daily dose of steroids and other anti-inflammatory drugs were reduced by more than 75% with a highly significant result. The hemoglobin level was also increased. Keywords: Ayurveda, ulcerative colitis, Udumbara kvatha basti, Basti karma
How to cite this article:
Patel MV, Patel KB, Gupta S N. Effects of Ayurvedic treatment on forty-three patients of ulcerative colitis. AYU 2010;31:478-81 |
| Introduction | |  |
Ulcerative colitis is a chronic inflammatory bowel disease. Its incidence is more during 20 to 40 years of age and 5-10 per 100,000 persons are at risk. [1] Bleeding in stool with increased bowel frequency are the cardinal features of this disease. Weakness is more common due to loss of water and blood in stool. In conventional Western medicine some drugs like sulfosalazine may give mild relief in symptoms and signs but after some time patients need more doses of the same drug. Some patients get benefit with steroids, which again are not suitable because of their side-effects. Even after taking steroids and sulfasalazine drugs patients suffer from the disease. So the patients are always seeking some alternative therapy promising more effective and safer outcomes.
The authors found some encouraging results in the patients of ulcerative colitis with certain Ayurvedic treatments. The treatment significantly corrected bleeding in stool and bowel frequency which are the cardinal features of ulcerative colitis, In addition the treatments also improved the general condition of the patient. Ulcerative colitis is a disease of Purishavaha srotas. In Ayurveda, Raktatisara is mentioned as an advanced stage of Pittatisara. Piccha basti also mentioned as a management of Raktatisara in Charaka Samhita.[2] This disease can be co-related with ulcerative colitis.
| Aims and Objectives | | |
The aims and objectives of this study were as follows -
- To prove the efficacy of Ayurvedic treatment in the management of ulcerative colitis.
- To provide a large population suffering from ulcerative colitis, a future possibility of safer treatment; this can be helpful in reducing the need of steroids and surgical processes.
| Materials and Methods | | |
Selection of patients
Forty-three cases with a classical picture of ulcerative colitis were randomly selected irrespective of age, sex, and chronicity from the OPD and IPD of the P. D. Patel Ayurveda Hospital, attached to J. S. Ayurveda College, Nadiad, Gujarat.
Criteria for inclusion
- Signs and symptoms of ulcerative colitis
- Colonoscopic diagnosis of ulcerative colitis
Criteria for exclusion
- Patients who had undergone surgeries
- Patients who had complications like anal fistula
- Patients with any other associated disease
Plan of study and treatments
- Proforma compiled with detailed clinical history and physical exam of the patients.
- Investigations like Hb g%, Erythrocyte sedimentation rate, Stool routine - microscopy and colonoscopy
- After confirming the diagnosis 43 patients were given the following treatment -
- Udumbara kvatha (ingredient is Udumbar tvak-Ficus glomerata) - 40 ml/two times a day
- Lodhra tvak churna (Symplocos racemosa) - 1 g + Musta moola churna (cyperus rotundus) - 1 g + Nagakesara (Mesua ferrea) churna - 1 g + Mukta panchamrut rasa-125 mg / three times in a day with water (the ingredients of Mukta panchamrut rasa are Mukta bhasma - 8 parts + Praval bhasma - 4 parts + Banga bhasma - 2 parts + Shankha bhasma - 1 part + Shukti bhasma - 1 part, processed in Ikshurasa, Godugdha, Vidai svarasa, Kumari svarasa, Shatavari Svarasa, Tulasi svarasa and Hansapadi svarasa).
- Kutaja Ghana vati (ingredient is Kutaja tvak-Holarrhena antidysenterica) - 1g / three times a day.
- Udumbara kvatha basti (ingredient is Udumbar tvak-Ficus glomerata) daily for one week and then twice a week for the next three weeks.
This treatment was given for a study period of one month.
Preparation of medicines
Medicines were prepared under expert supervision and purchased from Sunder Ayurveda Pharmacy, Nadiad.
Diet
Patients were kept on pitta -shamaka, laghu, grahi and pathya food articles.
If the patient was taking any modern medicine, doses of these were gradually reduced as the patient responded to Ayurvedic treatments.
Criteria for assessment
The improvement in the patients was assessed on the basis of relief in the symptoms and signs of the disease together with laboratory investigations. All the symptoms and signs were given grade scores and assessed before as well as after treatment. Changes in hemoglobin, ESR, and body weight were also recorded before and after treatment. Reductions in the doses of steroid and sulfasalazine drugs were also recorded.
| Observations, Results and Discussion | | |
Most of the patients (93.02%) belonged to the 20 - 40 years age group [Table 1]. In this study 65.12% of them were males and 34.88% were females [Table 2]. In other studies of modern medicines, the incidence of this disease in males and females is equal. Of the patients, 83.72% were Hindu [Table 3]; 46.51% had less than 1 year chronicity; 20.93% patients belonged to the 1 to 3 years chronicity group; 20.93% were found in the more than 3 to 5 years chronicity group. Only 11.63% patients were found in the more than 5 years' chronicity group [Table 4].
Bowel frequency was reduced by 81.81% and this benefit was statistically highly significant, Bleeding in stool was reduced by 91.58% and this was also statistically highly significant, Abdominal pain was reduced by 86.76% and this too was statistically highly significant, Weakness was reduced by 65.97%, again a statistically highly significant result, Body weight was increased by 2.31% and it was also statistically highly significant [Table 5]. Hemoglobin level was increased by 16.76%, which was statistically a highly significant result, ESR was decreased by 44.16% and it was also statistically highly significant, RBC in stool was decreased by 93.02% and it too was statistically highly significant, Pus cells in stool were decreased by 80.76% and it also was statistically highly significant [Table 6]. Forty-three patients had positive occult blood test before starting this treatment. Only four patients were found with positive occult blood test after the trial therapy. So 90.70% patients showed negative occult blood test after this treatment.[Table 7]. The drug prednisolone was taken by 16 patients in this study and the dose was reduced by 87.32%, that suggests a highly significant result, The dose of the sulfasalazine drug was reduced by 77.00% and it was also statistically highly significant [Table 8].None of the patients developed any new complication or new undesirable features [Table 9]. All the signs and symptoms, laboratory investigations and dose of steroids and sulfasalazine drugs were reduced, which was statistically highly significant. | Table 5: Effects of Ayurved therapy on signs and symptoms of ulcerative colitis
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 | Table 6: Effects of Ayurvedic therapy on investigations of patients of ulcerative colitis
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 | Table 8: Effects on reduction of the dose of steroids and sulfasalazine drugs
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Probable mode of action of the therapy
Ulcerative colitis is a disease of purisha vaha srotas which is caused by Pitta pradhana Vata doshas. Udumbara kvatha has properties of Pitta Vata shamana and also vrana shodana and ropana[3] which help in healing ulcers in the colon by basti karma. It also has stambhana properties that help in reducing the bowel frequency and check bleeding. Kutaja ghan vati[4] contains ghana satva of Kutaja tvak and has an Atisara nashaka (stambhana) guna that also helps in reducing the bowel frequency. Musta[5] with its grahi action relieves the ama in the body and also reduces the bowel frequency. Nagakeshara has Raktatisara nashaka[6] and Lodhra[7] has rakta stambhaka action that checks the bleeding. Mukta panchamrut rasa[8] is a classical compound Ayurveda drug that relieves excessive Pitta dosha and ushna guna in body. One of the ingredients of Mukta also relieves mental stress which is a contributing factor to the disease.
| Conclusion | | |
On the basis of our clinical observation and discussion, it may be concluded that ulcerative colitis was found in middle-aged people between 20 to 40 years of age. The results obtained may be attributed to the disease-modifying effect of the trial therapy by means of its anti-pitta, vranashodhana-ropana, grahi and stambhana properties. All the signs and symptoms were reduced by more than 80% and the reduction was statistically highly significant. RBCs in stool which is the main clinical sign of this disease was reduced by 93.02%. Hemoglobin increased by 16.76%. The dose of steroids was reduced by 87.32%. All the results were statistically highly significant. The trial therapy is an ideal drug as a safe and effective alternative in case of ulcerative colitis.
| Acknowledgment | | |
The authors are thankful to the management and the Principal of J.S Ayurveda College and P.D.Patel Ayurveda Hospital, Nadiad for providing the permission and facilities for this study.
| References | | |
| 1. | Davidson S. Davidson's Principles and Practice of Medicine. 16 th ed. Churchill: Livingstone Elsevier publication; 1995. p. 485. 
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| 2. | Agnivesha, Charaka, Dridhabala, Charaka samhita, Chikitsa Sthana, Atisara Chikitsa Adhyaya, 19/69-70 and 93-94, edited by Vaidya Jadavaji Trikamji Aacharya. 2 nd ed. Varanasi: Chaukhamba Sanskrit Sansthan;1990.
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| 3. | Bhavamishra, Bhavaprakash Nighantu, Vatadi Varga / 8-9, edited by Vishvanath Dvivedi. 9 th ed. Varanasi: Motilal Banarasidas prakashan; 1998. p. 339.
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| 4. | Ibidem (3), Bhavaprakash Nighantu, Guduchyadi varga / 111-112, page - 191.
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| 5. | Ibidem (3), Bhavaprakash Nighantu, Karpuradi varga / 82-84, page -128.
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| 6. | Dvivedi Vishvanath, Hindi commentator, Bhava prakash nighantu. 9 th ed. Varanasi: Motilal Banarasidas Prakashan;1998. p. 121.
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| 7. | Ibidem (3), Bhavaprakash Nighantu, Haritakyadi varga / 202-203, page -78.
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| 8. | The Ayurvedic pharmacopeia of India-- part - A, Rasayoga Vibhaga-20/29. 2 nd ed. Department of health and family welfare. Government of India. The controller of publication, civil line Delhi: 2003. p. 699.
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[Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6], [Table 7], [Table 8], [Table 9]
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