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CLINICAL RESEARCH
Year : 2010  |  Volume : 31  |  Issue : 4  |  Page : 461-465  

Clinical evaluation of the efficacy of Khadiradi yoga avachoornana in Kachchu with special reference to genitoinguinal intertrigo


1 Department of Prasuti Tantra and Stree Roga, SDM College of Ayurveda, Udupi, Karnataka, India
2 Department of Prasuti Tantra and Stree Roga, NIA, Jaipur, India

Date of Web Publication13-Jun-2011

Correspondence Address:
U Shubha
Department of Prasoothi Tantra and Stree Roga, SDM College of Ayurveda, Udupi, Kuthpady, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.82043

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   Abstract 

Kachchu is a simple localized dermatological infection of the genitoinguinal region, which occurs because of unhygienic observance, and manifests in the form of inflammation followed by secondary bacterial or fungal infections that can be best correlated to genitoinguinal intertrigo. Even though it rarely causes systemic manifestations, its mere presence itself is disturbing because of intractable itching and pain. It may delay the proper healing of the episiotomy wound and may cause difficulty in walking because of severe pain. Candida powder is the highest selling medicine for the intertrigo, as the incidence of intertrigo is as high as 40% in some particular seasons. In the Ayurveda fraternity, there is no established preparation that can be preserved safely in all the epochs of life in females and which is easy to apply. After understanding the disease in the perspective of the ayurvedic and modern medicinal systems, Khadiradi yoga choorna - a new ayurvedic formulation - was prepared on the basis of stringent ayurvedic principles. Hence, an attempt has been made to study the efficacy of the khadiradi yoga avachurnana 1 in Kachchu, with special reference to genitoinguinal intertrigo in females.

Keywords: Kachchu , itching, intertrigo


How to cite this article:
Mamatha K V, Shubha U, Jain C M. Clinical evaluation of the efficacy of Khadiradi yoga avachoornana in Kachchu with special reference to genitoinguinal intertrigo. AYU 2010;31:461-5

How to cite this URL:
Mamatha K V, Shubha U, Jain C M. Clinical evaluation of the efficacy of Khadiradi yoga avachoornana in Kachchu with special reference to genitoinguinal intertrigo. AYU [serial online] 2010 [cited 2020 Oct 31];31:461-5. Available from: https://www.ayujournal.org/text.asp?2010/31/4/461/82043


   Introduction Top


Human psyche has an innate tendency of confronting to get rid of any illness, simple or complicated, but definitely creating discomfort in that person. In this modern era, where etiquette is highlighted, people tend to be or pretend to be very neat with cultured social behaviors and a simple problem like intertrigo can cause a set back. In inguinal intertrigo, people feel a lot of discomfort as there is intense itching, and scratching in public places may be regarded as being uncultured. The altered gait due to severe discomfort may look awkward.

Kachhu / Vrushana Kachchu is a sthanika twak gata vikara explained in kshudra roga. Snana uthsadana hinatha are the predisposing factors, which cause itching in the genital region and because of scratching there will be manifestation of sphota and srava due to Kapha and Rakta prakopa. As the nidana and samprapti are not gender-specific, going by the word vrushana we have to consider the anatomical region and not the anatomical organ. [1]

Genitoinguinal intertrigo, [3] a mild form of superficial skin inflammation, may or may not be associated with secondary bacterial or fungal infection. It causes discomfort in the day-to-day activities, especially in pregnancy associated with obesity. In the costal regions, in particular, which have high humidity and hot climate and where there is severe sweating in both rainy and summer seasons, people are predisposed to get intertrigo. Diabetes and use of tight synthetic undergarments are the other factors that lead to intertrigo. The lesion may interfere in the healing of the episiotomy wound in the puerperal period. As the symptoms and etiological factors of kachchu and those of genitoinguinal intertrigo are similar, kachchu can be best correlated to genitoinguinal intertrigo The present study was carried out with the aim to evaluate the efficacy of Khadiradi Yoga Avachurnana in Kachchu / genitoinguinal intertrigo.


   Materials and Methods Top


Drug

Khadiradi yoga choorna has 11 drugs selected from different ganas. They are - Kustaghna gana, [3] (Khadira, Amalaki, Haritaki, Saptaparna, Haridra); Kandughna gana [3] (Mustaka, Nimba); Vedanastapana gana [3] (Shireesha); Bibhitaki [4] (on pralepa imparts dahahara property); and shudda gandhaka [8] and Dugdhapaashana[6] (both have the twakdoshahara property).

Sources of data

A minimum of 30 female patients suffering from genitoinguinal intertrigo were selected from the OPD and IPD of the SDM Hospital of Ayurveda Udupi, and taken for the study.

Method of collection of the data

It was a single blind clinical study, with a pre-test and post-test design, wherein, 60 diagnosed female patients of age group 20 - 50 years were selected. The patients were categorized into two groups of 30 patients each. The control group was given candid powder and the test group was given Khadiradi yoga choorna. A special proforma was prepared with all points of history taking, symptoms, physical signs and laboratory investigations as mentioned in our classics and allied sciences. The parameters of the signs and symptoms were scored on the basis of the standard method of statistical analysis.

Intervention

The drug powder was dusted on the affected area twice daily after cleaning the part with pre-boiled water and drying the area with clean gauze.

Dose Approximately 5 g of the powder was dusted on the surface of the affected skin twice in 24 hours.

Duration of administration : Three weeks.

Follow-up : For a total of one month with an interval of one week.

Investigations

Hemoglobin gm%, Total leucocyte count, Differential count, Erythrocyte sedimentation rate, Random blood sugar were carried out.

Inclusion criteria

  • Diagnosed cases of genitoinguinal intertrigo / Kachchu in otherwise healthy female patients aged 20 - 50 years.
  • Diagnosed cases of genitoinguinal intertrigo / Kachchu in pregnancy in all three trimesters and in the puerperal state.
  • Genitoinguinal intertrigo / Kachchu with gynecological conditions, wherein, administered drugs did not have any action on the lesion.


Exclusion criteria

  • Patients with intertrigo with other skin diseases, atrophic changes, with complications like septicemia.
  • Patients with systemic diseases like diabetes, HIV, and in a immunocompromised state or on steroid treatment.
  • Patients exhibiting allergic reaction to any of the constituents of the product used.
  • Intertrigo in locations other than the genitoinguinal region.


Assessment criteria

Assessment was made on the basis of changes in the following subjective and objective parameters: Subjective parameters - pain, itching

Objective parameters - size of the lesion, color, discharge, blisters


   Observations and Results Top


Presence of pain

All the patients had pain, but of a varied nature. Out of them, 65% of the women had intermittent pain and 35% women had continuous pain. In intertrigo, continuous pain is present in the presence of acute inflammation, and intermittent pain is present in the vaning stage of acute inflammation, and in the presence of intermittent friction,

Itching

Itching is an intractable symptom that is seen in this pathology. All the patients had itching. Eighty-five percent of the women presented with severe Kandu. Ten percent of the women presented with moderate Kandu, and 5% of the women presented with mild Kandu. Kandu is attributed to Kapha and is present due to maceration.

Size of the lesion

In 58.33% of the women, the intertrigous lesion had extended up to the vulva, in 36.67% the lesion had extended to the thighs, in 3.33% it had extended to the lower abdomen, and in 1.67% of the women it had extended to the buttocks. The ecosystem of the inguinal region and the vulva were similar and both were in the compact region. Therefore, the lesion tended to spread to the vulva. In obese females, it might even spread to the folds of the lower abdomen, thighs, or even to the buttocks.

Color

In the present study, out of 60 patients 43.33% of the women had a macerated lesion, 25% of the women had a blackish red lesion, 18.33% of the women had a blackish lesion, and 13.33% of the women had a red-colored lesion.

Presence of blisters

Only 16.67% of the women had development of blisters and 83.33% of the women never had blisters. As the sample size was small, it was inconclusive.

Effect of therapy

The effect of Khadiradi Yoga avachoornana and control group as well as the comparison between the two are presented in [Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6], [Table 7], [Table 8], [Table 9], [Table 10], [Table 11], [Table 12].
Table 1: Effect of therapy on pain


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Table 2: Comparison of effect of therapy on pain


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Table 3: Effect of therapy on itching


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Table 4: Comparison of effect of therapy on itching


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Table 5: Effect of therapy on size of lesion


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Table 6: Comparison of effect of therapy on size of lesion


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Table 7: Effect of therapy on color of lesion


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Table 8: Comparison of effect of therapy on color of lesion


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Table 9: Effect of therapy on Discharge


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Table 10: Comparison of effect of therapy on discharge


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Table 11: Effect of therapy on blisters


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Table 12: Comparison of effect of therapy on blisters


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   Discussion Top


Mode of action of Khadiradi choorna

The genitoinguinal region is an ecosystem of many bacteria and fungus. In normalcy, there would be some homeostasis in between. When there is a breech in the body immune system because of specific etiological factors, the balance in between the microorganisms is lost, as also the homeostasis between the genitoinguinal skin and the commensals gets impaired. Thus one or the other microorganism will get the pathogenicity and multiply in number to form colonies.

In the present study, the drug is used in a powder form. The very pathogenesis of Kachchu starts from the kledana of the mala present in the genitoinguinal region. The powder form of the drug and the presence of dugdha pashana and other kashaya rasa yukta drugs impart dryness to the skin of the genitoinguinal region. This will also break the chain of the pathogenesis causing kachchu. Most of the drugs have Kapha, Pitta-hara properties. Therefore, the Khadiradi yoga choorna pacifies the vitiated doshas responsible for the manifestation of Kachchu. Nimba and dugdha pashana have the lekhana property, which helps to remove the unwanted layer in that region. Moreover, haridra imparts luster.

Proteins and tannins present in the yoga impart dryness to the skin. Tannins constrict the opening of the gland ducts and cause peripheral vasoconstriction and reduce the oozing. Saponins and phenols act as cleansers and help in the debridement. Steroids are anti-inflammatories and thus analgesic. The glycosides present in the drugs directly act as anti-bacterial and anti-fungal agents.

The active principles of the drug may also act at the host tissue level and may undergo first-phase metabolism in the skin itself, before entering into the systemic circulation. This first phase metabolism of the drug in the skin fold of the genitoinguinal region may aid in many changes like alteration of pH and local temperature of that area, drying the skin of that area, and it may change the total local atmosphere of the local skin that has triggered the pathogenecity of microorganisms. Once the dampness of the area reduces, there is no nutritive media for the bacteria and fungus to grow, and hence, their growth may be reduced.

Even though the drug is applied in the powder form, some of its components, for example, the active principles, are dissolvable in the aqueous media. The interaction of the active principles of the drug with each other in that particular temperature and pH, with the microorganism or with the interactions of the microorganisms may act to combat the disease and help to heal the intertrigo.


   Conclusion Top


Genitoinguinal intertrigo is seen more often in pregnant and puerperal patients, as in both conditions there is increased sweating. It is more frequent in females with increased per vaginal discharges and per vaginal bleeding. Obesity and diabetes mellitus are the precipitating factors. All these conditions result in occlusion, leading to the improper disposal of sweat. Sweat retention increases friction between the skin folds and the pathology of the genitoinguinal region starts.

Avachoornana is the mode of procedure adopted to administer the drug as the disease Kachchu is a sthanika twakgata vikara. Avachoornana acts for both purposes of shodhana and ropana, as mentioned in the classics. This clinical study done with the objective to see the clinical efficacy of Khadiradi yoga avachoornana in Kachchu shows that itching, dampness, and blisters respond to khadiradi choorna better than candida., Khadiradi choorna has a similar effect on pain, color, and size of the lesion as that of the candida powder, which has proved its efficacy.

 
   References Top

1.Sushruta, Sushruta Samhita with Nibandhasangraha of Dalhanacharya and Nyayachandrika Panchika of Gayadasa. Yadava T. Nidhana Stana. 7 th ed. Varanasi: Chaukhambha Surabharati Prakashana; 2002. p. 824.  Back to cited text no. 1
    
2.Textbook and Atlas of Dermatology. Valia RG, editor. 2 nd ed. Bombay: Bhalani Publishing House; 2003. p. 768.  Back to cited text no. 2
    
3.Agnivesha, Charaka Samhita, revised by Charaka and Dradabala, with Ayurveda Deepika commentary by Choukamba chakrpanidutta. Yadav T, editor. Sutrastana. 5 th ed. Varanasi: Sanskrit Samstan; 2001. p. 738.  Back to cited text no. 3
    
4.Agnivesha, Charaka Samhita, revised bt Charaka and Dradabala, with Ayurveda Deepika commentary by chakrpanidutta. Yadav T, editor. Chikitsastana. 5 th ed. Varanasi: Choukamba Sanskrit Sanstan; 2001. p. 489.   Back to cited text no. 4
    
5.Vagbhatacharya, Rasaratna Samuchchaya with suratnojjala commentary edited by Ambikadatta Shastry, 9 th edition1995, Published at Chaukhambha Amarabharati Prakashan, Varanasi, 3/17.  Back to cited text no. 5
    
6.Sharma S. Rasataranginiwith prasadini vyakya by Sri Haridatta shastry. Shastry K, editor. 11 th ed. Chaukhambha Publications; New Delhi: 2004. p. 772  Back to cited text no. 6
    



 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6], [Table 7], [Table 8], [Table 9], [Table 10], [Table 11], [Table 12]



 

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