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   2012| April-June  | Volume 33 | Issue 2  
    Online since December 29, 2012

 
 
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REVIEW ARTICLES
Medicinal and cosmetic uses of Bee's Honey - A review
E. R. H. S. S Ediriweera, N. Y. S Premarathna
April-June 2012, 33(2):178-182
DOI:10.4103/0974-8520.105233  PMID:23559786
Bee's honey is one of the most valued and appreciated natural substances known to mankind since ancient times. There are many types of bee's honey mentioned in Ayurveda. Their effects differ and 'Makshika' is considered medicinally the best. According to modern scientific view, the best bee's honey is made by Apis mellifera (Family: Apidae). In Sri Lanka, the predominant honey-maker bee is Apis cerana. The aim of this survey is to emphasize the importance of bee's honey and its multitude of medicinal, cosmetic and general values. Synonyms, details of formation, constitution, properties, and method of extraction and the usages of bee's honey are gathered from text books, traditional and Ayurvedic physicians of Western and Southern provinces, villagers of 'Kalahe' in Galle district of Sri Lanka and from few search engines. Fresh bee's honey is used in treatment of eye diseases, throat infections, bronchial asthma, tuberculosis, hiccups, thirst, dizziness, fatigue, hepatitis, worm infestation, constipation, piles, eczema, healing of wounds, ulcers and used as a nutritious, easily digestible food for weak people. It promotes semen, mental health and used in cosmetic purposes. Old bee's honey is used to treat vomiting, diarrhea, rheumatoid arthritis, obesity, diabetes mellitus and in preserving meat and fruits. Highly popular in cosmetic treatment, bee's honey is used in preparing facial washes, skin moisturizers, hair conditioners and in treatment of pimples. Bee's honey could be considered as one of the finest products of nature that has a wide range of beneficial uses.
  13,953 2,295 22
ORIGINAL ARTICLES - CLINICAL RESEARCH
Safety and efficacy evaluation of Ayurvedic treatment (Arjuna powder and Arogyavardhini Vati) in dyslipidemia patients: A pilot prospective cohort clinical study
Gajendra Kumar, Amita Srivastava, Surinder Kumar Sharma, Yogendra Kumar Gupta
April-June 2012, 33(2):197-201
DOI:10.4103/0974-8520.105238  PMID:23559790
Cardiovascular disease has multifaceted in which dyslipidemia, inflammation, and immunity play an important role. Arjuna powder and Arogyavardhini Vati used for centuries has potential for combating these factors. Therefore, the objective of this study was to evaluate the safety and efficacy of Ayurvedic treatment (Arjuna powder and Arogyavardhini Vati) for dyslipidemia patients. Total of 108 patients were screened at CGHS Ayurvedic Hospital, New Delhi. Ninety-six patients satisfied inclusion criteria, and signed informed consent and detailed medical history was recorded. Arjuna powder (5 g, BD) for 3 weeks and then Arogyavardhini Vati (500 mg, BD) for 4 weeks were prescribed to the patients. The primary efficacy endpoint was reduction in serum total cholesterol, LDL, triglycerides, and increased HDL levels. Secondary endpoints included reduction in serum C-Reactive Protein (CRP) and blood glucose levels. Safety assessments included hepatic function (aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, and β2 microglobulin), renal function (urea and creatinine and NGAL) tests, and urine mercury level. The study was completed by 87 patients. The male and female patients were 65.5% (57/87) and 34.5% (30/87), respectively. There was a significant reduction in total cholesterol, LDL, triglycerides, CRP, and blood glucose. However, raised HDL level was also observed. Safety assessment results showed no significant change in serum ALT, AST, ALP and bilirubin, urea, creatinine β2 microglobulin, and NGAL levels at the end of study as compared to the baseline levels. In conclusion, the results of the present prospective cohort study showed that Ayurvedic treatment (Arjuna powder and Arogyavardhini Vati) is safe and effective for dyslipidemia.
  14,420 985 5
REVIEW ARTICLES
Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies
Vinay K Gupta, Seema Malhotra
April-June 2012, 33(2):193-196
DOI:10.4103/0974-8520.105237  PMID:23559789
Aloe vera has long been used as a traditional medicine for inducing wound healing. It is a natural product that now a days is used in cosmetic industry. Benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves though there are various indications for its use. Biological activities include promotion of wound healing, antifungal activity, anti-inflammatory, anticancer and immunomodulatory. Gingival fibroblasts play an important role in oral wound healing. Double blind-controlled trials are needed to determine its real efficacy in oral health.
  9,890 1,521 12
A critical study of Rasamritam and it's applied aspects
Sudhaldev Mohapatra, Ramesh K Gupta, K.R.C Reddy, Chandra Bhushan Jha
April-June 2012, 33(2):183-187
DOI:10.4103/0974-8520.105235  PMID:23559787
Historical studies of Rasa shastra reveal the use of metals and minerals, both for alchemical and therapeutical purposes in ancient past. But, gradually the alchemical use of the subject, declines and the therapeutical use takes over. Rasamritam is the latest doctrine in the field of Rasa shastra which compiles the extract of the older books and adopted some new and contemporary concepts. The practical aspects of this text influence both the academicians as well as physicians in large extent. Keeping the wealthier, timely concept of this text in mind, we are trying to review and analyze it critically for the benefit of researchers and practitioners and hope the idea will be fruitful.
  7,144 986 -
SHORT COMMUNICATIONS
Effect of fennel on pain intensity in dysmenorrhoea: A placebo-controlled trial
Shabnam Omidvar, Sedighe Esmailzadeh, Mahmood Baradaran, Zahra Basirat
April-June 2012, 33(2):311-313
DOI:10.4103/0974-8520.105259  PMID:23559811
The aim of this study was to determine the clinical effect of Foeniculum vulgare on primary dysmenorrhoea. Sixty virgin girls with complaints of dysmenorrhoea were enrolled in this study, out of which 50 cases were completed the course of treatment and were divided in two groups (study and placebo) and were under treatment for two cycles. In study group a capsule of 30 mg fennel extract, four times a day for three days from start of their menstrual period and in placebo a capsule containing wheat flour in same dose was administered. Intensity of pain was reported by using a 10 - point linear analogue technique. In study group the mean age of menarche was 13.1 ± 0.1 and onset age of dysmenorrhoea was 14.5 ± 0.1 years. Both groups were relieved but there was significant difference between study and placebo group. Study group shown more effective results than placebo in pain relief (P<0.05). Based on the observations, it can be concluded that, fennel is an effective herbal drug for menstrual pain.
  6,501 839 11
CASE REPORT
Urushiol-induced contact dermatitis caused during Shodhana (purificatory measures) of Bhallataka (Semecarpus anacardium Linn.) fruit
R llanchezhian, C Roshy Joseph, Acharya Rabinarayan
April-June 2012, 33(2):270-273
DOI:10.4103/0974-8520.105250  PMID:23559802
Bhallataka (Semecarpus anacardium Linn.; Ancardiaceae) is mentioned under Upavisha group in Ayurvedic classics and it is described as a poisonous medicinal plant in Drugs and Cosmetics Act (India), 1940. Fruit of Bhallataka is used either as a single drug or as an ingredient in many compound formulations of Indian systems of medicine to cure many diseases. Tarry oil present in the pericarp of the fruit causes blisters on contact. The major constituent of the tarry oil is anacardic acid and bhilawanol, a mixture of 3-n-pentadec(en)yl catechols. Bhilawanol A and B are known as Urushiols, and also, anacardic acid is closely related to Urushiol. Urushiol-induced contact dermatitis is the medical name given to allergic rashes produced by the oil Urushiol. This paper deals with five case reports of contact dermatitis caused during different stages of Shodhana (purificatory measures) of Bhallataka fruit due to improper handling of the utensils and disposal of media used in Shodhana procedure and their Ayurvedic management. To combat these clinical conditions, the affected persons were advised external application with pounded Nimba (Azadirachta indica A. Juss.) leaves on the affected parts and internal administration of Sarivadyasava 30 ml thrice daily after food and Triphala Churna 5 g before food twice daily. Reduction of itching and burning sensation was observed after topical application.
  5,617 571 4
PHARMACEUTICAL STANDARDIZATION
Analytical profile of Brahmi Ghrita: A polyherbal Ayurvedic formulation
Jyoti S Gubbannavar, Harimohan Chandola, CR Harisha, Renuka Kalyani, Vinay J Shukla
April-June 2012, 33(2):289-293
DOI:10.4103/0974-8520.105254  PMID:23559806
Brahmi Ghrita, a polyherbal Ayurvedic formulation is recommended in the management of various psychological disorders like Unmada, Apasmara and Graharogas. The present study deals with the pharmacognostical identification of ingredients of Brahmi Ghrita and its physico-chemical analysis. Pharmacognostical study containing both macroscopic and powder microscopy of raw drug revealed the quality and genuineness of all the constituents of Brahmi Ghrita. Organoleptic features of coarse powder made out of the crude drugs were within the standards prescribed. Acid value was 0.16075, saponification value 184.17, Refractive Index value 1.467 at room temperature, Iodine value 26.715, Specific gravity at room temperature was 0.9133. HPTLC was carried out after organizing appropriate solvent system in which maximum 9 spots were distinguished and most of the R f values were identical in alcoholic extract which shows the presence of certain definite constituents in Brahmi Ghrita.
  4,831 666 4
Pharmacognostical and analytical study of Tulsi-Amla-Yasti Ghrita
Debdas Datta, Harimohan Chandola, SK Agarwal, Vinay J Shukla, Preeti N Pandya
April-June 2012, 33(2):274-278
DOI:10.4103/0974-8520.105251  PMID:23559803
Tulasi Amla Yashti Ghrita is an Ayurvedic formulation, which is beneficial in the management of the side effects of Head and Neck Malignancies induced by Radiotherapy and Chemotherapy. A pharmacognostical study involving both the macroscopic and powder microscopy of raw drugs of Tulasi Amla Yashti Ghrita and a physicochemical analysis of the finished product were carried out, to evaluate the quality of the formulation. The specific gravity of the formulation was 0.9130 and pH was 3.5. Thin layer chromatography (TLC) and high performance thin layer chromatography (HPTLC) were carried out after organizing the appropriate solvent system, in which five spots were distinguished in TLC and nine spots in HPTLC. Most of the R f values for the spots observed were identical. The observations could be considered to be the reference standards in future studies.
  4,619 561 1
ORIGINAL ARTICLES - CLINICAL RESEARCH
Development and validation of a Prototype Prakriti Analysis Tool (PPAT): Inferences from a pilot study
Sanjeev Rastogi, Francesco Chiappelli
April-June 2012, 33(2):209-218
DOI:10.4103/0974-8520.105240  PMID:23559792
Prakriti , for its tangible impacts upon decision making in Ayurvedic clinical practice, requires a thorough and fool-proof method of examination. Conventional methods adopted for Prakriti examination are found inconsistent with huge inter- and intra-rater inference variability. By observing the gaps in the field, the present study aims to develop a prototype Prakriti analysis tool and its evaluation on inter-rater validity grounds. The study observes that Vata and Pitta constructs of Prakriti identification in Ayurveda have a significant inter-rater correlation (P < 0.001 and P < 0.01), whereas Kapha has less (P < 0.02) correlation. It is inferred that for less correlated variables like those of Kapha, a better understanding is required to reach a better consensus.
  3,870 911 5
Clinical efficacy of Guduchyadi Medhya Rasayana on Senile Memory Impairment
R. D. H Kulatunga, Alankruta R Dave, Madhav Singh Baghel
April-June 2012, 33(2):202-208
DOI:10.4103/0974-8520.105239  PMID:23559791
Aging has become one of the distinctive demographic phenomena in the 21 st century and its social, economic and health implications are the most challenging issues. Senile Memory Impairment is a common condition characterized by mild symptoms of cognitive decline and occurs as a part of the normal aging process. It can be correlated to "Jarajanya Smrtibhramsha" according to Ayurveda. The present study deals with the efficacy of Guduchyadi Medhya Rasayana on Senile Memory Impairment. A total of 138 patients aged in between 55-75 years were registered and randomly divided into two groups as the trial and control groups. The drugs were administered for 3. The trial drug showed memory enhancement, anti-stress, anti-depressant and anxiolytic properties. The trial group showed better results in the management compared to the control group.
  4,003 562 -
EDITORIAL
New challenges for Ayurveda: How it will stand?
HM Chandola
April-June 2012, 33(2):165-166
DOI:10.4103/0974-8520.105231  PMID:23559783
  3,518 779 -
REVIEW ARTICLES
Sushruta-samhitA - A critical Review Part-1 : Historical glimpse
Hari S Sharma, Hiroe I Sharma, Hemadri A Sharma
April-June 2012, 33(2):167-173
DOI:10.4103/0974-8520.105232  PMID:23559784
In the history of Ayurveda, Sushruta stands before Caraka. He practically applied Vaidika culture for treatment. His treatise translated into nine foreign languages apart from various Indian languages like Hindi, Bengali, Malayalam, etc., Sushruta is the most celebrated physician and surgeon in India. Though he practiced during the 5th century BC, many of his contributions to medicine and surgery preceded similar discoveries in the western world. Sushruta devotes a complete volume of his experiences to ophthalmologic diseases. In the Uttara Tantram, Sushruta enumerates a sophisticated classification of eye diseases complete with signs, symptoms, prognosis, and medical/surgical interventions. In particular, Sushruta describes what may have been the first extracapsular cataract surgery using a sharply pointed instrument with a handle fashioned into a trough. His ability to manage many common eye conditions of the time with limited diagnostic aids is a testament to his virtuosity.
[ABSTRACT]   Full text not available  [PDF]  [Mobile Full text]  [EPub]  [PubMed]
  3,284 983 -
PHARMACOLOGICAL STUDY
Anti-inflammatory activity of two varieties of Pippali (Piper longum Linn.)
Mamta Kumari, BK Ashok, B Ravishankar, Tarulata N Pandya, Rabinarayan Acharya
April-June 2012, 33(2):307-310
DOI:10.4103/0974-8520.105258  PMID:23559810
The present study has beenundertaken to evaluate the anti-inflammatory activity of two varieties of Pippali in acute and sub-acute experimental models of inflammation in albino rats. Four different market samples of each variety of Pippali were procured from different regions of India. The samples collected from South India which have given more extractive values were selected for screening of anti-inflammatory activity. Randomly selected animals were divided into four groups of six animals each. The test drugs were administered orally at a dose of 200 mg/kg and the activity was compared with standard anti-inflammatory drugs in both models. Among the two different test samples studied, it was found that Chhoti variety of Pippali suppressed inflammation of both acute and sub acute phase, while Badi variety of Pippali only of acute phase. Thus for the therapeutic utility, Chhoti variety of Pippali may be considered over the Badi variety.
  3,406 701 4
ORIGINAL ARTICLES - CLINICAL RESEARCH
Effect of Shatapushpa Taila Matra Basti and Pathadi Kwatha on Poly Cystic Ovarian Disease
Krupa D Patel, Laxmipriya Dei, Shilpa B Donga, Nalini Anand
April-June 2012, 33(2):243-246
DOI:10.4103/0974-8520.105245  PMID:23559797
Poly Cystic Ovarian Disease (PCOD) is a complex disorder affecting 5-15% women in their reproductive age and related to ovarian dysfunction, characterized by menstrual irregularities, hyperandrogonism, obesity, and infertility. In Ayurveda, these symptoms are found under various conditions, caused by vitiated Vata and Kapha. Pathadi Kwatha and Shatapushpa Taila Matra Basti were studied in the current attempt to evaluate their comparative efficacy in cases of PCOD. Total 34 patients of PCOD were registered among which, 32 had completed the treatment of 2 months. They were randomly divided in to three groups. In group A Pathadi Kwatha (10 g, bid) and Shatapushpa Taila Matra Basti (60 ml for 7 days after cessation of menses for 2 consecutive cycles) were administered. In group B only Basti, whereas in group C capsules of roosted wheat flour were administered. Better results were obtained in group A especially in menstrual irregularities, achieving follicular growth and in weight reduction.
  3,241 728 -
REVIEW ARTICLES
Self evolution: 1 st domain of spiritual health
Neera Dhar, Suresh K Chaturvedi, Deoki Nandan
April-June 2012, 33(2):174-177
DOI:10.4103/0974-8520.105234  PMID:23559785
While measuring physical, mental, and social health as defined by the World Health Organization (WHO), the basis of measurement is in terms of Determinants. Recently with the advent of health promotion activities, the emphasis is on enabling individuals, groups, and societies to have control on these Determinants. To measure the spiritual health, the 4 th Dimension, a Spiritual Health Scale consisting of 3 Domains, 6 Constructs, and 27 Determinants of spiritual health were identified through a scientific process. A statistically reliable and valid Spiritual Health Scale (SHS 2011) containing 114 items has been developed. Construct validity and test-retest reliability has been established. The 3 Domains are: Self-Evolution, Self-Actualization, and Transcendence. In this article, the process of self evolution in terms of "Wider Perspective" and "Nurturance-Art" have been captured through the Determinants like Commitment, Introspection, Honesty, Creativity, Contemplation, Prayer, Philanthropy, Extending Self, Empathy, Yoga and Exercise, Questioning Injustice, Aesthetics, Value for Time, and Being Away From Comparisons.
  3,075 646 5
ORIGINAL ARTICLES - CLINICAL RESEARCH
Clinical efficacy of Shiva Guggulu and Simhanada Guggulu in Amavata (Rheumatoid Arthritis)
Shweta A Pandey, Nayan P Joshi, Dilip M Pandya
April-June 2012, 33(2):247-254
DOI:10.4103/0974-8520.105246  PMID:23559798
Amavata is the second most common joint disorders. Nowadays erroneous dietary habits, lifestyle and environment have led to various autoimmune disorders i.e. Amavisajanya Vikaara and Amavata is one among them. Rheumatoid arthritis can be correlated with Amavata in view of its clinical features. Many research studies have been done to solve this clinical enigma, but an effective, safe, less complicated treatment is still required for the management of Amavata. In the present study, 24 patients of Amavata were registered and randomly grouped into two. In group A, Shiva Guggulu 6 g/day in divided doses and in group B, Simhanada Guggulu 6 g/day in divided doses were given for 8 weeks. On analysis of the results, it was found that Simhanada Guggulu provided better results as compared to Shiva Guggulu in the management of Amavata.
  3,186 481 -
Clinical efficacy of Shodhana Karma and Shamana Karma in Mandala Kushtha (Psoriasis)
Gunjan Mangal, Gopesh Mangal, Radhey Shyam Sharma
April-June 2012, 33(2):224-229
DOI:10.4103/0974-8520.105242  PMID:23559794
In India an estimated 0.8% of the population is suffering from Psoriasis. It is a papulo-squamous disorder of the skin, characterized by sharply defined erythemato-squamous lesions. It is chronic and is well known for its course of remissions and exacerbations. The exact etiology is still unknown. This condition is comparable with Mandala Kushtha in Ayurvedic system of medicine. Shodhana procedures are reliable to control the disease. Forty patients, fulfilling the inclusion criteria, were selected and randomly divided into four groups with 10 patients in each group. In Group A, Vamana and Virechana was administered once during the trial period. In Group B, Vamana and Virechana followed by Dermo-care in the dose of 5 g twice a day for the period of 2 months. In Group C, only Dermo-care was administered. In Group D, Tab. Neotrexate (Methotrexate) 7.5 mg/week was given under the supervision of dermatologist. Marked improvement was observed in 10% of the patients in Group B. Moderate improvement was observed in 20% of the patients in Group A, 90% in Group B, and 80% in Group D. Mild improvement was observed in 80% of the patients in Group A, 100% in Group C, and 20% in Group D.
  2,986 621 -
Critical study of Jara (aging) and its management
Nisha Parmar, Mahesh Vyas, Hitesh Vyas
April-June 2012, 33(2):264-269
DOI:10.4103/0974-8520.105249  PMID:23559801
Jara Avastha (stage of old age) is the later phase of life in which maximum decline of bodily elements is observed. Paramanuvibhaga (cell division) takes place at every moment; particularly in old age, it will be fast in comparison with other phases of life. Some organ related changes also take place during this period, which are the decades of Balya, Vridhhi, Chhavi, Medha, Twak, etc., In this study, applied aspects of Medha Hani, Twak Hani, and Drishti Hani were evaluated subjectively as well as objectively. Patients were selected from the OPD of Department of Basic Principles, I.P.G.T. and R.A., Gujarat Ayurved University, Jamnagar, irrespective of their sex, caste, religion, etc., and randomly divided into two groups. Patients in Group A were treated with Panchagavya Ghrita and Group B with plain Go Ghrita for 90 days and the dose of drug was 10 g/day at Nirannakala (early morning with empty stomach). Both groups showed significant results, the difference in between the groups is statistically insignificant.
  3,001 524 -
SHORT COMMUNICATIONS
Anti-ulcer activity of Lucer against experimentally induced gastric ulcers in rats
Jigna S Shah, Jetun R Patel
April-June 2012, 33(2):314-316
DOI:10.4103/0974-8520.105260  PMID:23559812
The present study is designed to explore the mechanism of action of herbal formulation Lucer against experimentally induced gastric ulcers. The aqueous extract (120 and 180 mg/kg) of Lucer was tested against aspirin and ethanol-induced gastric ulcer model in rats. The drug has been found to be very effective in inhibiting gastric ulceration. This is evident from reduction in ulcer index parameters. Besides, significant reduction in acid secretory parameters such as total acidity, total acid output and volume of gastric secretion were also observed. It is concluded from this study that the drug possesses anti-ulcer activity in both the models. The anti-ulcer activity of the drug can be attributed to inhibition of acid secretary parameters and strengthening of gastric mucosal barrier.
  2,961 416 2
REVIEW ARTICLES
Applicability and importance of Caraka's concept of Aaturaparijnana Hetawah in understanding a patient
Rupesh Wadher, Rambabu R Dwivedi
April-June 2012, 33(2):188-192
DOI:10.4103/0974-8520.105236  PMID:23559788
Many concepts in Ayurveda are untouched or unexplored till date. One of such concepts to understand the healthy and unhealthy persons is that of the Aaturaparijnana Hetawah (APH), which is only mentioned in Caraka Samhita. The descriptions about Dushya, Desha, Bala, Kala, Prakriti, etc. are mentioned very briefly in all the classics. But no standard figure or pattern is maintained while considering them. It is only in the description of Aaturaparijnana Hetawah mentioned in Vimana Sthana that all the factors are pre-arranged in a chronological order to understand an individual according to one's Desha as from birth till grown up stage, and also to understand about the illness and most common disorders. In this article, it is aimed at presenting an in-depth evaluation about description of Aaturaparijnana Hetawah in Ayurveda. For this study, the references of Aturaparijnana Hetu have been collected through the Ayurvedic texts along with their commentaries. By making use of 14 factors described in Aaturaparijnana Hetawah, it is possible to have an in depth understanding about the patient's nature and factors that may be contributing to his health and illness. Aaturaparijnana Hetawah helps in an in-depth understanding of a patient's disease and heath status. More in-depth evaluation studies and application in the modern medical science should be done in order to avail the benefits of this approach.
  2,576 520 -
ORIGINAL ARTICLES - CLINICAL RESEARCH
Clinical efficacy of Shankhapushpi and a herbo-mineral compound in type-II diabetes
Dhananjay V Patel, Harimohan Chandola, Madhav Singh Baghel, Jayesh R Joshi
April-June 2012, 33(2):230-237
DOI:10.4103/0974-8520.105243  PMID:23559795
Diabetic population is more than 245 million worldwide and expected to be >380 million by 2025. One of the main causes of increasing rate of diabetes is stress and tension in day-to-day life, disturbing the homeostasis of positive and negative emotions to initiate pathophysiology of stress-induced diabetes. In the present study, in Group A of 34 patients, a herbo-mineral compound containing Shuddha Shilajatu, Shuddha Guggulu, Vijayasara Ghana, Saptarangi Ghana, and Triphala Ghana was administered in the dose of 3 gm/day in three divided doses with luke-warm water before meal for the duration of 8 weeks, which significantly relieved symptoms (60.52%) like Prabhuta Mutrata (54.55%), Avila Mutrata (66.67%), Daurbalya (61.36%), Shrama (59.32%), etc. with fasting blood sugar (4.05%) and postprandial blood sugar (9.95%). In another series of 34 patients (Group B), where psychological health promoting drug Shankhapushpi was administered in the dose of 1.5 gm/day in three divided doses for 8 weeks along with herbo-mineral compound. The percentage relief was found to be more better on symptoms (71.13%) like Prabhuta Mutrata (76.92%), Avila Mutrata (83.33%), Daurbalya (75%), Shrama (70.37%), fasting blood sugar (18.04%) and postprandial blood sugar (27.75%). Group B showed better results on psychological parameters like disturbed Manasabhava (29.16%) and Brief Psychiatry Rating Scale (38.28%). The high significance of χ2 (15.50) on overall effect of therapy indicated better results in group B.
  2,548 496 1
Clinical effect of Virechana and Shamana Chikitsa in Tamaka Shwasa (Bronchial Asthma)
Kuntal A Ghosh, Paresh C Tripathi
April-June 2012, 33(2):238-242
DOI:10.4103/0974-8520.105244  PMID:23559796
To evaluate comparative efficacy of Samshodhana and Samshamana Chikitsa, the current study is planned in 24 patients of Tamaka Shwasa. Thirteen patients (Group A) were treated with Samshodhana, particularly with Virechana Karma. The patients of this group received Abhyantara Snehana with Tila Taila followed by Bahya Snehana with Tila Taila and Saindhava Lavana. After observations of proper signs of Snehana; Virechana Karma was performed with Aragvadha Phala Majja. Samsarjana Krama was followed for five days. Subsequently all the patients were given the trial drug (powder of Badara). The patients of group B, were treated only with the powder of dried ripe fruits of Badara. In both groups, the dose of Badara powder was 5 g, twice a day, with luke warm water, for a period of 60 days. In group A, maximum number of patients (61.45 %) showed good response, while in group B, 45.45 % patients showed good response. No side effects were observed during the clinical trial. Based on the observations, it was concluded that, group A is more effective than group B.
  2,499 442 -
Clinical efficacy of Jalaukawacharana (leech application) in Thrombosed piles
Pradnya J Bhagat, Subhash Y Raut, Arun M Lakhapati
April-June 2012, 33(2):261-263
DOI:10.4103/0974-8520.105248  PMID:23559800
'Arsha' (hemorrhoids) is an ailment that affects all economical groups of population. Though the disease is within the limits of management, it has its own complications like severe hemorrhage, inflammation, and thrombosis, by which a patient gets severe pain and is unable to continue his routine work. Prior to surgical treatment of hemorrhoids, associated conditions like inflammation, strangulation, thrombosis, etc. need to be managed. Thrombosed piles possibly occur due to high venous pressure associated with severe anal pain. Leech (Hirudina medicanalis) application is found to be effective in reducing pain. In thrombosed piles, leech application has shown thrombolytic action, which contributes in re-establishment of circulation. It is observed in the study that, pus and mucous discharge have been reduced after leech application; which may be due to antimicrobial and mucolytic properties of leech. This method of treatment is found to be effective and increase the quality of life in patients suffering with thrombosed piles.
  2,479 438 2
PHARMACEUTICAL STANDARDIZATION
Pharmacognostical and phytochemical studies of Curcuma neilgherrensis (Wight) leaf - A folklore medicine
M Shyam Prasad, Anju P Ramachandran, Harimohan Chandola, CR Harisha, Vinay J Shukla
April-June 2012, 33(2):284-288
DOI:10.4103/0974-8520.105253  PMID:23559805
Curcuma neilgherrensis Wight is a folk medicinal plant used in the management of diabetes mellitus. The leaves of this herb are said to be successful in managing high blood glucose levels. This study is aimed at assessing the scientific appraisal of C. neilgherrensis in the course of pharmacognostical characters and phytochemical parameters, as these are not yet been done. Pharmacognostic study mainly covered the macroscopic and microscopic features of the leaves including powder microscopy, and revealed the presence of trichomes, spiral vessels etc. Phytochemical parameters such as pH, total ash value, water-soluble extract and MeOH extract values were assessed in the preliminary physicochemical screening. Qualitative analysis revealed the existence of certain chemical constituents such as flavonoids, tannins, organic acids and saponin glycosides. The crude extract of leaves was subjected to TLC and HPTLC for the separation of components.
  2,315 457 -
ORIGINAL ARTICLES - CLINICAL RESEARCH
Clinical efficacy of two different samples of Shirishavaleha in Tamaka Shwasa (Bronchial Asthma)
Shyamlal Singh Yadav, Galib , Biswajyoti Patgiri, Pradeep Kumar Prajapati
April-June 2012, 33(2):255-260
DOI:10.4103/0974-8520.105247  PMID:23559799
Incidences of Bronchial Asthma have been raised in recent decades due to increased industrialization and pollution. This miserable condition can be compared with Tamaka Shwasa in Ayurveda. Modern synthetic drugs will provide instant relief in these cases, but are tend to develop a number of adverse drug reactions. Knowing this, the current suffering population is looking towards few remedies from other systems of medicines, that are comparatively safe and provide better relief. Shirisha [Albizzia lebbeck Benth] is a drug with multi-dimensional activities emphasized in Ayurveda for different disease conditions. Considering this, two types of Shirishavaleha (confection of Shirisha) were prepared by Kwatha (decoction) of Twak (bark) and Sara (heartwood) of Shirisha to evaluate its comparative efficacy in Tamaka Shwasa (bronchial asthma). The results were assessed in terms of clinical recovery, symptomatic relief and pulmonary function improvement. A significant increase in Hb and considerable decrease in total eosinophil count, AEC and ESR were observed. The study revealed that Shirishavaleha can be used as an effective drug in bronchial asthma.
  2,076 468 1
Clinical evaluation of the efficacy of Dashanga Kwatha Ghana Vati in the management of Urdhwaga Amlapitta (Non-ulcer dyspepsia)
Umapati C Baragi, Mahesh K Vyas
April-June 2012, 33(2):219-223
DOI:10.4103/0974-8520.105241  PMID:23559793
A study has been designed to evaluate the effectiveness of Dashanga Kwatha Ghana Vati in Urdhwaga Amlapitta (non-ulcer Dyspepsia). Randomized single blind, placebo controlled study was conducted in 138 patients attending O.P.D. of department of Basic Principles, I.P.G.T. and R.A., Gujarat Ayurved University, Jamnagar, and grouped into two. Both the groups consumed two tablets of either Dashanga Kwatha Ghana Vati or placebo, twice daily after food for a period of eight weeks. The patients were followed upto four weeks, 110 patients had completed the treatment and no adverse effects were reported during the treatment. Both groups had improved in the clinical symptoms and overall statistical significance was observed in the differences of scores between the two groups.
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PHARMACEUTICAL STANDARDIZATION
Development of Random Amplified Polymorphic DNA markers for authentification of Cissus repanda vahl.
CR Harisha, Rabinarayan Acharya, Maltiben G Chauhan
April-June 2012, 33(2):279-283
DOI:10.4103/0974-8520.105252  PMID:23559804
Cissus repanda Vahl. belongs to the family Vitaceae, commonly known in Hindi as "Panivel," is a large climber distributed all over India. The crushed or powder of root is prescribed by tribal people and traditional medical practitioners of Orissa for its healing properties in cases of bone fracture, cuts and wounds, swellings, and so on. In spite of its reputation, its leaves have not been investigated scientifically. The present study deals with pharmacognostical and molecular characterization by Random Amplified Polymorphic DNA (RAPD) markers and their role in laying down standardization and pharmacopoeial parameters. Genomic isolation of DNA from fresh leaves was amplified by RAPD markers. The diagnostic characters are mucilage, calcium oxalate rosette crystals, spiral vessels, and fibers. The unique bands obtained in Polymerase Chain Reaction (PCR) amplification clearly discriminated having, many bright and light bands indicating the genuinity of the plant. RAPD may serve as a complementary tool in quality control of many herbal sources.
  2,186 311 -
Pharmaceutical standardization of Mamajjaka (Enicostemma littorale Auct. non Bl) Ghana
Samir P Tanna, Biswajyoti Patgiri, Vinay J Shukla, Pradeep Kumar Prajapati
April-June 2012, 33(2):294-298
DOI:10.4103/0974-8520.105255  PMID:23559807
Mamajjaka (Enicostemma littorale Auct. non Bl) is a well known folklore medicine frequently used for the treatment of Madhumeha (diabetes mellitus). There is no direct reference available for its antihyperglycaemic activity in Ayurvedic classics. Considering this, a study is planned towards developing pharmaceutical standardization of Mamajjaka Ghana. In this study, five batches of Mamajjaka Ghana were prepared and findings were systematically recorded to maintain the Standard Operating Procedure (SOP). An average of 14.78% Ghana was obtained. The physico-chemical parameters, qualitative test for various functional groups, quantitative estimation of total alkaloids, HPTLC profile, heavy metal analysis and microbial overload were carried out of Mamajjaka Ghana.
  2,002 409 1
PHARMACOLOGICAL STUDY
Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats
Rajendra Kumar Singh, Rita Banerjee, Sachhidananda Upadhyay, Achintya Mitra, Jayram Hazra
April-June 2012, 33(2):303-306
DOI:10.4103/0974-8520.105257  PMID:23559809
The present study was carried out to assess the safety of standardized Panchakola Avaleha on albino rats (Wistar strain). Animals were administered three doses of Panchakola Avaleha by oral routes, viz. higher (500 mg/kg/day), middle (250 mg/kg/day), and therapeutic dose (50 mg/ kg/ day) for 28 consecutive days. Effects of the test drug on hematological, biochemical, and histopathologic parameters were evaluated. This study revealed normal behavior, no mortality, and no significant changes in hematological, biochemical, and histopathological examinations.
  1,972 391 1
In vitro antimicrobial and brine shrimp lethality of Allophylus cobbe L.
Md. Torequl Islam, Md. Abdun Noor, Bijoy Karon, Rivelilson Mendes de Freitas
April-June 2012, 33(2):299-302
DOI:10.4103/0974-8520.105256  PMID:23559808
Plants are rich source of pharmacologically active agents, which could be explored in disease management. Methanol, ethanol, and petroleum ether extracts of the whole plant of Allophylus cobbe L. were evaluated for antimicrobial and cytotoxic activities. In vitro antimicrobial sensitivity by disk diffusion method was conducted against four Gram-positive and seven Gram-negative pathogenic bacteria and seven fungi. In the antibacterial and antifungal sensitivity tests, growth inhibition was found to be within the range of 10.0-17.67 mm. Strong zone of inhibition by the ethanol extract of A. cobbe (EEAC) was found against Trichophyton spp. With some exceptions, a mild to strong antimicrobial activity was observed in this study. Significant minimum inhibitory concentration (MIC; 15.625 μg/ml) was found against Trichophyton spp. Other detected MICs were within the range of 31.25-125 μg/ml. The petroleum ether extract of the plant exhibited strong cytotoxicity in the brine shrimp lethality bioassay test.
  1,802 330 -
LETTERS TO EDITOR
Effect of Majja Basti (therapeutic enema) and Asthi Shrinkhala (Cissus quadrangularis) in the management of Osteoporosis (Asthi-Majjakshaya)
Bhagath Kumar Potu, Muddanna S Rao, Srinivas Rao Sirasanagandla
April-June 2012, 33(2):317-318
DOI:10.4103/0974-8520.105263  PMID:23559813
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Aerobic isotonic exercise and Prameha (diabetes mellitus) as per Prakriti
Beuy Joob, Viroj Wiwanitkit
April-June 2012, 33(2):317-317
DOI:10.4103/0974-8520.105262  PMID:23559814
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Water purification
Somsri Wiwanitkit, Viroj Wiwanitkit
April-June 2012, 33(2):317-317
DOI:10.4103/0974-8520.105261  PMID:23559815
  1,183 288 -
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