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ORIGINAL ARTICLES - CASE REPORTS
Management of Amavata (rheumatoid arthritis) with diet and Virechanakarma
Sanjay Kumar Gupta, Anup B Thakar, Tukaram S Dudhamal, Aditya Nema
October-December 2015, 36(4):413-415
DOI:10.4103/0974-8520.190688  PMID:27833370
Amavata is a disease in which vitiation of Vata Dosha and accumulation of Ama take place in joint(s), and it simulates rheumatoid arthritis (RA) at modern parlance. Shamana (conservative) and Shodhana (biological purification of the body) treatments are advised in Ayurveda whereas anti-inflammatory, analgesics, steroids, and disease-modifying antirheumatic drugs are required for its management as per modern medicine, which are not free from side effects. A female was suffering from multiple joints pain with swelling, severe morning stiffness, restricted movements, malaise, and Mandagni (poor appetite) for the past 1½ year, which was classified as Amavata/RA (having 7/10 score as per the RA classification criteria, 2010). After Deepana-Pachana and Snehapana, Virechanakarma was done by the administration of Trivrita Avaleha and castor oil. The assessment was made on the basis of relief in signs and symptoms and serological findings of RA factor, C-reactive protein (CRP), immunoglobulin E (IgE), and erythrocyte sedimentation rate. After Virechanakarma, RA factor reduced from 94.0 IU/ml to 50.0 IU/ml, CRP reduced from 22.7 mg/L to 1.8 mg/L, and IgE was reduced from 680 kU/L to 53.7 kU/L, with remarkable reduction in joints pain and swelling. Further, by avoiding specific Nidanas, i.e., known allergens for food, drugs, and inhalants, the patient has relief in almost all signs and symptoms for the past 1 year of follow-up with least medications. This single case report highlights that Amavata/RA can be managed with appropriate diet regimen, Virechanakarma and can be managed effectively with minimum requirement of medicines.
  31,387 1,208 -
ORIGINAL ARTICLES - CASE STUDIES
Ayurvedic intervention in the management of uterine fibroids: A Case series
Kamini Dhiman
July-September 2014, 35(3):303-308
DOI:10.4103/0974-8520.153750  PMID:26664240
Uterine enlargement is common in reproductive life of a female. Other than pregnancy, it is seen most frequently in the result of leiomyomas. Leiomyomas, are benign smooth muscle neoplasmas that typically originate from the myometrium, due to fibrous consistency and are also called as fibroid. They may be identified in asymptomatic women during routine pelvic examination or may cause symptoms. Typical complaints include pain, pressure sensations, dysmenorrhea or abnormal uterine bleeding. Management of uterine fibroid through surgery is available to meet urgent need of the patient, but challenges remain to establish a satisfactory conservatory medical treatment till date. Hence, it was critically reviewed in the context of Granthi Roga (disease) and treatment protocol befitting the Samprapti Vighatana of Granthi (encapsulated growth) was subjected in patients of uterine fibroids. Seven cases of uterine fibroid were managed by Ayurvedic intervention. Ultrasonography (USG) of the lower abdomen was the main investigative/diagnostic tool in this study. After 7 weeks, patients presented with USG report as absence of uterine fibroid. Ayurvedic formulations Kanchanara Guggulu, Shigru Guggulu, and Haridra Khand are found to be effective treatment modality in uterine fibroid.
  30,994 993 2
ORIGINAL ARTICLES - CLINICAL RESEARCH
Effect of Kumari Taila Uttar Basti on fallopian tube blockage
Kamayani Shukla (Upadhyay), Kaumadi Karunagoda, Nita Sata, LP Dei
October-December 2010, 31(4):424-429
DOI:10.4103/0974-8520.82031  PMID:22048533
The present study was carried out to evaluate the role of Uttar Basti in tubal blockage, in order to establish it as a safer and cost-effective Ayurvedic treatment modality. The criteria for selection of patients and assessment of results were unilateral or bilateral tubal blockage diagnosed in hysterosalpingography (HSG). A total of 16 patients in the reproductive age group were registered for the study, with 62.50% unilateral and 37.50% bilateral tubal blockage. Fifteen patients completed the course of treatment. The patients with an evidence of active infection or chronic diseases were excluded. Kumari Taila was selected for its Vata Kapha Shamaka and Lekhana properties. The dose of Uttar Basti was 5 ml with duration of two consecutive cycles (six days of Uttar Basti in each cycle with an interval of three days in between). Uttar Basti was administered, after cessation of menstruation, to the screened patients, through hematological, urinary, and serological (HIV, VDRL, HBsAg) investigations. The tubal blockage was removed in 80% of the patients, and 40% of the patients had conceived within the follow-up period of two months. The results suggest that Uttar Basti is a highly significant treatment modality for tubal blockage, with no apparent complications.
  29,041 1,334 -
CASE STUDY
An Ayurvedic treatment protocol to improve anti-mullerian hormone: A prerequisite for assisted reproductive technique- A case report
Anjaly Muraleedharan, Parvathy Unnikrishnan, Priyadarshana Narayan, Hemavathi Shivapura Krishnarajabhatt
January-June 2017, 38(1):66-69
DOI:10.4103/ayu.AYU_167_17  PMID:29861596
Anti-Mullerian hormone (AMH) produced by granulosa cells of preantral and antral follicles acts as a potential marker for ovarian reserve useful in predicting ovarian response to controlled ovarian stimulation. A woman undergoing in vitro fertilization (IVF) with low AMH has poor success rate and ultimately the couple is left with the only option of IVF with a donor egg. The signs and symptoms of a patient with low AMH level can be compared to Dhatukshayajanya Vandhyata. The present case report documents the efficacy of an Ayurvedic treatment protocol in improving the AMH value, which is a prerequisite for assisted reproductive technique (ART) without a donor egg. The patient with low AMH level was subjected to Ayurvedic management protocol including Shamana for 3 months and Shodhana procedure for 21 days. The follow-up was done for 3 months. A marked improvement in the AMH level was noted in the first 3 months and also after the follow-up period, thus making her eligible for ART with her own egg.
  28,222 548 -
ORIGINAL ARTICLES - CLINICAL RESEARCH
Effects of Ayurvedic treatment on 100 patients of chronic renal failure (other than diabetic nephropathy)
Manish V Patel, SN Gupta, Nimesh G Patel
October-December 2011, 32(4):483-486
DOI:10.4103/0974-8520.96120  PMID:22661841
Chronic renal failure (CRF) refers to an irreversible deterioration in renal function, which develops over a period of years. This initially manifests only as a biochemical abnormality. CRF is considered when glomerular filtration rate (GFR) falls below 30 ml/min. The conventional approach of management includes dialysis and renal transplantation, which are not affordable by Indian population mainly due to economic reasons. Therefore, exploration of a safe and alternative therapy is needed, which proves to be helpful in reducing the requirement of dialysis and in postponing the renal transplantation. A clinical study of 100 patients of CRF was conducted at OPD and IPD of PD Patel Ayurved Hospital, Nadiad. They were given Niruha basti of Punarnavadi kvatha daily with oral medicaments including Goksuradi guggulu, Rasayana churna, and Varunadi kvatha for 1 month period. The patients of CRF, having diabetic nephropathy as a cause, were excluded since a separate study for diabetic nephropathy is being conducted. Results were analyzed statistically using the "t " test. The symptoms and signs, serum creatinine, blood urea, urine albumin level were reduced, which were found to be statistically highly significant on "t " test.
  26,511 1,881 1
REVIEW ARTICLES
Intellectual property rights and patents in perspective of Ayurveda
Anand Chaudhary, Neetu Singh
January-March 2012, 33(1):20-26
DOI:10.4103/0974-8520.100298  PMID:23049179
Ayurveda is getting its due recognition as a rationale system of medicine worldwide despite the fact that medical and scientific fraternity of the globe has very strong opposite opinion regarding safety and efficacy of Ayurvedic medicines. Meanwhile, provisions of Intellectual Property Rights under World Intellectual Property Organization (WIPO) and Patents have attracted many individuals and organizations to explore possibilities of commercial benefits with Ayurvedic traditional knowledge. Although rules are not favoring to grant a patent on prior published knowledge, biopiracy managed grant of Patent on knowledge of Ayurvedic medicinal plants which has been successfully checked with references of data base of Traditional Knowledge Digital Library (TKDL). Current provisions of the Patent law of India are obstructive in nature for getting patent on Ayurvedic medicines. If we have to invite researchers from basic science to ensure quality, safety and efficacy of Ayurvedic medicines, there is an urgent need to amend laws of patent with pragmatic promotional policies. This will encourage more patents on numerous pharmaceutical, nutraceutical and cosmaceutical products based on Ayurveda. As every action of today's world is based on economic criteria so why stakeholders of Ayurveda should be deprived of it. New inventions would drive acceptance of Ayurveda as a global system of medicine.
  15,946 1,189 1
Viruddha Ahara : A critical view
Mukund Sabnis
July-September 2012, 33(3):332-336
DOI:10.4103/0974-8520.108817  PMID:23723637
Viruddha Ahara is a unique concept described in Ayurveda. The present article deals with the critical review of Viruddha Ahara referred in terms of food-food interactions, food processing interactions. Ayurveda clearly defines that certain diet and its combinations, which interrupts the metabolism of tissue, which inhibits the process of formation of tissue and which have the opposite property to the tissue are called as Viruddha Anna or incompatible diet. The food which is wrong in combination, which has undergone wrong processing, which is consumed in incorrect dose, which is consumed in incorrect time of day and in wrong season can lead to Viruddha Ahara. The article narrates the modern perspective of Samskar Viruddha, Veerya Viruddha, Samyoga Viruddha, and so on. It also enlists a variety of incompatible dietary articles consumed in today's day-to-day life and its hazardous effects on health.
  15,053 1,941 -
RESEARCH ARTICLES
Ayurvedic Management of Avascular Necrosis of the Femoral Head - A Preliminary Study
Sanjay M Kadlimatti, PG Subbanagouda, AI Sanakal, Milind Deshpande
July-September 2008, 29(3):154-160
Among the many conditions that affect bones, Avascular Necrosis (AVN) is one in which bone tissue is necrosed (dead) due to the injury or any occlusion in the blood vessels nourishing the bone tissue. Avascular necrosis of the femoral head is the most common type of necrosis affecting the bones. AVN of the femoral head may be classified mainly into 2 types, 1. Post traumatic and 2. Idiopathic. The arteries supplying the femoral head are very narrow and hence are easily liable to injury followed by mere dislocation or a sub capital fracture (near the head) of the femoral neck. This leads to the lack of nourishment to femoral head resulting in necrosis. In the other type, the arteries become occluded for which the reason is not known. It may be asymptomatic in the beginning but, later mild to severe degree of pain is seen along with change in the gait. Management is not an easy task. The objectives of the treatment include the preservation of structure & function and relief of pain. Many surgical procedures like Drilling and Insertion of Bone Grafts, Modified Whitman or Colonna reconstruction and insertion of prosthesis is carried out. All these procedures are cost worthy and prognosis is very poor. An effort was made to evaluate the efficiency of Ayurvedic formulations in the conservative management of AVN of the femoral head. Four patients of Idiopathic AVN of the femoral head were treated with Tikta Dravya Siddha Ksheera Basti, Abha Guggulu and Ajasthi Bhasma. The results were encouraging. The therapy provided marked relief from pain, tenderness, general debility and improvement in the gait. The grade of AVN did not worsen and was maintained. The therapy is cost effective.
[ABSTRACT]   Full text not available   
  15,926 0 -
REVIEW ARTICLE
Ayurvedic research and methodology: Present status and future strategies
Ashutosh Chauhan, Deepak Kumar Semwal, Satyendra Prasad Mishra, Ruchi Badoni Semwal
October-December 2015, 36(4):364-369
DOI:10.4103/0974-8520.190699  PMID:27833362
Ayurveda is a science of life with a holistic approach to health and personalized medicine. It is one of the oldest medical systems, which comprises thousands of medical concepts and hypothesis. Interestingly, Ayurveda has ability to treat many chronic diseases such as cancer, diabetes, arthritis, and asthma, which are untreatable in modern medicine. Unfortunately, due to lack of scientific validation in various concepts, this precious gift from our ancestors is trailing. Hence, evidence-based research is highly needed for global recognition and acceptance of Ayurveda, which needs further advancements in the research methodology. The present review highlights various fields of research including literary, fundamental, drug, pharmaceutical, and clinical research in Ayurveda. The review further focuses to improve the research methodology for Ayurveda with main emphasis on the fundamental research. This attempt will certainly encourage young researchers to work on various areas of research for the development and promotion of Ayurveda.
  13,140 2,140 -
CLINICAL RESEARCH
A pilot study on Ayurvedic management of oral submucous fibrosis
Kundan R Patel, Manjusha Rajagopala, Dharmendrasinh B Vaghela, Ashok Shah
January-March 2015, 36(1):34-40
DOI:10.4103/0974-8520.169018  PMID:26730136
Introduction: Oral submucous fibrosis (OSMF) is a chronic debilitating disease and a well-recognized potentially premalignant condition of the oral cavity. Various medical and surgical treatment modalities have been used in modern science, but results are not satisfactory owing to recurrence, adverse effects, and sometimes worsening the condition. On analyzing the disease condition with Ayurvedic approach, it seems to be nearer to Vata-Pitta dominant chronic Sarvasara Mukharoga and needs to be treated at local as well as systemic level. Aim: To evaluate the effect of proposed Ayurvedic treatment protocol in the patients of OSMF. Materials and Methods: It was an open-label nonrandomized clinical trial with black box design comprising of holistic Ayurvedic approach in which 22 patients of OSMF completed the treatment. In all of them after Koshthashuddhi (mild purgation) and Shodhana Nasya (errhine therapy); Pratisarana (external application) with Madhupippalyadi Yoga, Kavala (gargling) with Ksheerabala Taila and internally Rasayana Yoga were given for 2 months and followed for 1 month. Results: It revealed statistically highly significant relief in almost all signs and symptoms as well in inter incisal distance improvement. Furthermore, sustained relief was found in follow-up. Conclusion: Ayurvedic treatment protocol is effective in the management of OSMF.
  11,733 702 -
ORIGINAL ARTICLES
The effect of ghee (clarified butter) on serum lipid levels and microsomal lipid peroxidation
Hari Sharma, Xiaoying Zhang, Chandradhar Dwivedi
April-June 2010, 31(2):134-140
DOI:10.4103/0974-8520.72361  PMID:22131700
Ghee, also known as clarified butter, has been utilized for thousands of years in Ayurveda as a therapeutic agent. In ancient India, ghee was the preferred cooking oil. In the last several decades, ghee has been implicated in the increased prevalence of coronary artery disease (CAD) in Asian Indians due to its content of saturated fatty acids and cholesterol and, in heated ghee, cholesterol oxidation products. Our previous research on Sprague-Dawley outbred rats, which serve as a model for the general population, showed no effect of 5 and 10% ghee-supplemented diets on serum cholesterol and triglycerides. However, in Fischer inbred rats, which serve as a model for genetic predisposition to diseases, results of our previous research showed an increase in serum total cholesterol and triglyceride levels when fed a 10% ghee-supplemented diet. In the present study, we investigated the effect of 10% dietary ghee on microsomal lipid peroxidation, as well as serum lipid levels in Fischer inbred rats to assess the effect of ghee on free radical mediated processes that are implicated in many chronic diseases including cardiovascular disease. Results showed that 10% dietary ghee fed for 4 weeks did not have any significant effect on levels of serum total cholesterol, but did increase triglyceride levels in Fischer inbred rats. Ghee at a level of 10% in the diet did not increase liver microsomal lipid peroxidation or liver microsomal lipid peroxide levels. Animal studies have demonstrated many beneficial effects of ghee, including dose-dependent decreases in serum total cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL), and triglycerides; decreased liver total cholesterol, triglycerides, and cholesterol esters; and a lower level of nonenzymatic-induced lipid peroxidation in liver homogenate. Similar results were seen with heated (oxidized) ghee which contains cholesterol oxidation products. A preliminary clinical study showed that high doses of medicated ghee decreased serum cholesterol, triglycerides, phospholipids, and cholesterol esters in psoriasis patients. A study on a rural population in India revealed a significantly lower prevalence of coronary heart disease in men who consumed higher amounts of ghee. Research on Maharishi Amrit Kalash-4 (MAK-4), an Ayurvedic herbal mixture containing ghee, showed no effect on levels of serum cholesterol, high density lipoprotein (HDL), LDL, or triglycerides in hyperlipidemic patients who ingested MAK-4 for 18 weeks. MAK-4 inhibited the oxidation of LDL in these patients. The data available in the literature do not support a conclusion of harmful effects of the moderate consumption of ghee in the general population. Factors that may be involved in the rise of CAD in Asian Indians include the increased use of vanaspati (vegetable ghee) which contains 40% trans fatty acids, psychosocial stress, insulin resistance, and altered dietary patterns. Research findings in the literature support the beneficial effects of ghee outlined in the ancient Ayurvedic texts and the therapeutic use of ghee for thousands of years in the Ayurvedic system of medicine.
  10,317 1,878 15
REVIEW ARTICLES
Medicinal and cosmetic uses of Bee's Honey - A review
E. R. H. S. S Ediriweera, N. Y. S Premarathna
April-June 2012, 33(2):178-182
DOI:10.4103/0974-8520.105233  PMID:23559786
Bee's honey is one of the most valued and appreciated natural substances known to mankind since ancient times. There are many types of bee's honey mentioned in Ayurveda. Their effects differ and 'Makshika' is considered medicinally the best. According to modern scientific view, the best bee's honey is made by Apis mellifera (Family: Apidae). In Sri Lanka, the predominant honey-maker bee is Apis cerana. The aim of this survey is to emphasize the importance of bee's honey and its multitude of medicinal, cosmetic and general values. Synonyms, details of formation, constitution, properties, and method of extraction and the usages of bee's honey are gathered from text books, traditional and Ayurvedic physicians of Western and Southern provinces, villagers of 'Kalahe' in Galle district of Sri Lanka and from few search engines. Fresh bee's honey is used in treatment of eye diseases, throat infections, bronchial asthma, tuberculosis, hiccups, thirst, dizziness, fatigue, hepatitis, worm infestation, constipation, piles, eczema, healing of wounds, ulcers and used as a nutritious, easily digestible food for weak people. It promotes semen, mental health and used in cosmetic purposes. Old bee's honey is used to treat vomiting, diarrhea, rheumatoid arthritis, obesity, diabetes mellitus and in preserving meat and fruits. Highly popular in cosmetic treatment, bee's honey is used in preparing facial washes, skin moisturizers, hair conditioners and in treatment of pimples. Bee's honey could be considered as one of the finest products of nature that has a wide range of beneficial uses.
  9,898 2,094 20
EDITORIALS
Nourishing the tree of Ayurveda: Enriched with specialty!
HM Chandola
October-December 2011, 32(4):443-444
DOI:10.4103/0974-8520.96111  PMID:22661832
  2,403 9,423 -
ORIGINAL ARTICLES - CASE STUDY
A single case study of treating hypertrophic lichen planus with Ayurvedic medicine
Kshirod Kumar Ratha, Laxmidhar Barik, Ashok Kumar Panda, Jayram Hazra
January-March 2016, 37(1):56-61
DOI:10.4103/ayu.AYU_1_16  PMID:28827956
Ayurvedic medicines are often considered effective for chronic and lifestyle disorders. Hypertrophic lichen planus (HLP) is a rare inflammatory skin condition and develops into squamous cell carcinoma in few cases. It has resemblance with Charma Kushtha mentioned in Ayurvedic classics. Conventional therapy used in this condition is unsatisfactory and is not free from side effects. A case of long-standing systemic steroid-dependent HLP is presented here which was intervened successfully with Ayurvedic modalities.
  11,274 540 -
CLINICAL RESEARCHES
Clinical efficacy of Ayurveda treatment regimen on Subfertility with poly cystic ovarian syndrome (PCOS)
SA Dayani Siriwardene, L.P.A Karunathilaka, ND Kodituwakku, Y.A.U.D Karunarathne
January-March 2010, 31(1):24-27
DOI:10.4103/0974-8520.68203  PMID:22131680
Poly Cystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, resulting from insulin resistance and the compensatory hyperinsulinemia. This results in adverse effect on multiple organ systems and may result in alteration in serum lipids, anovulation, abnormal uterine bleeding and infertility. According to Ayurvedic view PCOS can be correlated with Aarthava Kshaya. It was revealed that most of subfertility patients who were presented Osuki Ayurveda Centre suffered from the PCOS. Therefore the present study was carried out for the clinical evaluation of the efficacy of Ayurveda treatment regimen on subfertility with PCOS. Total 40 patients were selected by using purposive sampling method. According to the Ayurveda theories of Shodhana, Shamana and Tarpana, the treatment was conducted in 3 stages for the duration of 6 months. The response to the treatment was recorded and therapeutic effects were evaluated by symptomatic relief and through Trans Vaginal Scan and LH, FSH hormone levels. The results revealed that, subfertility due to PCOS can be cured successfully by using this Ayurveda treatment regimen.
  9,521 1,803 1
EDITORIAL
Reinvent the system of Education in Ayurveda
Harimohan Chandola
October-December 2012, 33(4):459-460
DOI:10.4103/0974-8520.110502  PMID:23723659
  2,331 8,986 -
INNOVATIVE ARTICLE
Drug discovery from plant sources: An integrated approach
Chandrakant Katiyar, Arun Gupta, Satyajyoti Kanjilal, Shefali Katiyar
January-March 2012, 33(1):10-19
PMID:23049178
New drug discovery is facing serious challenges due to reduction in number of new drug approvals coupled with exorbitant rising cost. Advent of combinatorial chemistry provided new hope of higher success rates of new chemical entities (NCEs); however, even this scientific development has failed to improve the success rate in new drug discovery. This scenario has prompted us to come out with a novel approach of integrated drug discovery, where Ayurvedic wisdom can synergize with drug discovery from plant sources. Initial steps in new drug discovery involve identification of NCEs, which can be either sourced through chemical synthesis or can be isolated from natural products through biological activity guided fractionation. The sources of many of the new drugs and active ingredients of medicines are derived from natural products. The starting point for plant-based new drug discovery should be identification of the right candidate plants by applying Ayurvedic wisdom, traditional documented use, tribal non-documented use, and exhaustive literature search. Frequency analysis of the ingredients of the ancient documented formulations and analysis of their Ayurvedic attributes may provide an in-depth idea of the predominance of particular Ayurvedic characteristics based on which appropriate candidate plants may be selected for bioactivity-based fractionation. The integration of Ayurvedic wisdom with drug discovery also brings the need for a paradigm shift in the extraction process from sequential to parallel extraction. Bioassay-guided fractionation of the identified plant may lead to standardized extract or isolated bioactive druggable compound as the new drug. This integrated approach would lead to saving of cost and time, coupled with enhanced success rate in drug discovery.
  9,192 2,019 -
REVIEW ARTICLES
Medohara and Lekhaniya dravyas (anti-obesity and hypolipidemic drugs) in Ayurvedic classics: A critical review
Harshitha Kumari, Reshmi Pushpan, K Nishteswar
January-March 2013, 34(1):11-16
DOI:10.4103/0974-8520.115437  PMID:24049399
Santarpanottha Vikaras (diseases due to excessive nutrition) are increasing during current times. Medodushti (disorders of fat metabolism) serves as one of the important etiological factor in most of these disorders including Ischemic Heart Disease (IHD). IHD is identified as one of the leading cause of morbidity and mortality worldwide in both developing and developed countries. Retention and deposition of serum lipids resulting in decreased flow of blood in coronary arteries being the underlying cause. Conventional and herbal drugs are being used to lower levels of serum cholesterol to prevent this menace. In this regard, an attempt has been made to critically review the Medohara and Lekhaniya (Anti-obesity and Hypolipidemic) drugs mentioned in Ganas (group of drugs) of Ayurvedic classical texts which may abet our understanding of prevention and management of conditions like Dyslipidemia and its complications. Administration of drugs possessing Tikta Rasa (bitter taste), Ushna Veerya (hot in potency), Laghu and Ruksha Guna (light and dry qualities), Katu Vipaka and Vata Kaphahara actions were noted during the analysis.
  9,549 1,345 4
EDITORIAL
Depleting medicinal plant resources: A threat for survival of Ayurveda
K Nishteswar
October-December 2014, 35(4):349-350
DOI:10.4103/0974-8520.158972  PMID:26195893
  2,443 8,406 1
Headway in Ayurveda: Miles to go
Mahesh Vyas
October-December 2015, 36(4):359-360
DOI:10.4103/0974-8520.190690  PMID:27833360
  2,949 7,609 -
REVIEW ARTICLES
Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies
Vinay K Gupta, Seema Malhotra
April-June 2012, 33(2):193-196
DOI:10.4103/0974-8520.105237  PMID:23559789
Aloe vera has long been used as a traditional medicine for inducing wound healing. It is a natural product that now a days is used in cosmetic industry. Benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves though there are various indications for its use. Biological activities include promotion of wound healing, antifungal activity, anti-inflammatory, anticancer and immunomodulatory. Gingival fibroblasts play an important role in oral wound healing. Double blind-controlled trials are needed to determine its real efficacy in oral health.
  8,609 1,394 11
ORIGINAL ARTICLES - CLINICAL RESEARCH
A comparative clinical study of Snuhi Ksheera Sutra, Tilanala Kshara Sutra and Apamarga Kshara Sutra in Bhagandara (Fistula in Ano)
Supreeth Joyal Lobo, C Bhuyan, SK Gupta, TS Dudhamal
January-March 2012, 33(1):85-91
DOI:10.4103/0974-8520.100319  PMID:23049190
Bhagandara (Fistula in Ano) at modern parlance is a common anorectal condition prevalent in the populations worldwide and its prevalence is second highest after Arsha (hemorrhoids). Kshara Sutra (K.S.) is one of the chief modality in the treatment of Bhagandara in Ayurvedic science. Exploration of the new plants for the preparation of Kshara as a better substitute to Apamarga Kshara is the need of the hour. To find out an effective alternative to Apamarga K.S. in view of easy processing, a Snuhi Ksheera Sutra without any Kshara and the Tilanala K.S. were opted for their clinical evaluation. Total 33 cases of Bhagandara were divided randomly into 3 groups, having 11 patients in each group. In Group A, Snuhi Ksheera Sutra; in Group B, Tilanala K.S. and in Group C, Apamarga K.S. were used. Assessment was done on objective (Unit Cutting Time - UCT) and subjective parameters. Statistically insignificant difference was observed in the efficacy of treatment by subjective parameters like pain, discharge, etc. between the three groups. It was found that Tilanala K.S. showed higher UCT (9.76 days) while lower in Snuhi Ksheera Sutra (7.42 days) as compared to Apamarga K.S. (8.82 days). Thus Tilanala K.S. can be used as a substitute for Apamarga K.S. and Snuhi Ksheera Sutra can be employed in the recurrent fibrosed cases of Bhagandara.
  9,208 783 1
Safety and efficacy evaluation of Ayurvedic treatment (Arjuna powder and Arogyavardhini Vati) in dyslipidemia patients: A pilot prospective cohort clinical study
Gajendra Kumar, Amita Srivastava, Surinder Kumar Sharma, Yogendra Kumar Gupta
April-June 2012, 33(2):197-201
DOI:10.4103/0974-8520.105238  PMID:23559790
Cardiovascular disease has multifaceted in which dyslipidemia, inflammation, and immunity play an important role. Arjuna powder and Arogyavardhini Vati used for centuries has potential for combating these factors. Therefore, the objective of this study was to evaluate the safety and efficacy of Ayurvedic treatment (Arjuna powder and Arogyavardhini Vati) for dyslipidemia patients. Total of 108 patients were screened at CGHS Ayurvedic Hospital, New Delhi. Ninety-six patients satisfied inclusion criteria, and signed informed consent and detailed medical history was recorded. Arjuna powder (5 g, BD) for 3 weeks and then Arogyavardhini Vati (500 mg, BD) for 4 weeks were prescribed to the patients. The primary efficacy endpoint was reduction in serum total cholesterol, LDL, triglycerides, and increased HDL levels. Secondary endpoints included reduction in serum C-Reactive Protein (CRP) and blood glucose levels. Safety assessments included hepatic function (aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, and β2 microglobulin), renal function (urea and creatinine and NGAL) tests, and urine mercury level. The study was completed by 87 patients. The male and female patients were 65.5% (57/87) and 34.5% (30/87), respectively. There was a significant reduction in total cholesterol, LDL, triglycerides, CRP, and blood glucose. However, raised HDL level was also observed. Safety assessment results showed no significant change in serum ALT, AST, ALP and bilirubin, urea, creatinine β2 microglobulin, and NGAL levels at the end of study as compared to the baseline levels. In conclusion, the results of the present prospective cohort study showed that Ayurvedic treatment (Arjuna powder and Arogyavardhini Vati) is safe and effective for dyslipidemia.
  8,967 878 5
EDITORIALS
Need of new research methodology for Ayurveda
MS Baghel
January-March 2011, 32(1):3-4
DOI:10.4103/0974-8520.85711  PMID:22131749
  7,760 1,906 3
ORIGINAL ARTICLES - CLINICAL RESEARCH
A study on Tailabindu pariksha-An ancient Ayurvedic method of urine examination as a diagnostic and prognostic tool
Pavan Kumar Sangu, Vanitha Murali Kumar, Meera Shiv Shekhar, Murali Krishna Chagam, Penchala Prasad Goli, Prasanna Kumar Tirupati
January-March 2011, 32(1):76-81
DOI:10.4103/0974-8520.85735  PMID:22131762
Indian traditional medicine, Ayurveda has a great history. Researchers in India have tried to corroborate ancient wisdom with the modern scientific practices. Tailabindu pariksha is a diagnostic tool of urine examination developed by the medieval Ayurvedic scholars, and also throws a light on the prognosis of the disease condition. This study aims at using this ancient wisdom to diagnose the medical conditions and to study about their prognosis, and studying about how it can be applied to modern medical practice and its limitations. For the purpose of the study, 30 volunteers were divided into 3 groups. Group I consisting of healthy volunteers, group II of those patients who suffer from curable conditions and group III consisting of patients suffering from chronic diseases which can be regarded as incurable. The urine collection, oil drop instillation and evaluation, were all done according to the guidelines laid down in Ayurvedic practices. Upon the evaluation of the color, appearance, consistency and pattern of oil drop spreading in different patients of different groups, it could be seen that the data could be correlated to what has been provided in the literature in majority of the cases. In today's modern medical practices, there is a plethora of urine diagnostic examinations available. These act as an added financial burden to the patients. In the midst of this, making use of Tailabindu pariksha for urine examination, will not only prove economical, but also is a time-tested and scientifically proven method. More in-depth studies on larger groups of patients, suffering from various diseases need to be done to standardize the procedure and make it scientifically more acceptable.
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