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PHARMACOLOGICAL STUDY
Year : 2018  |  Volume : 39  |  Issue : 2  |  Page : 101-106

Antioxidant, antibacterial, antidiarrheal and antipyretic activities of organic crude fractions of Commelina paludosa


1 Department of Pharmacy, University of Science and Technology Chittagong, Foys Lake, Pahartali (Chittagong), Bangladesh
2 Department of Pharmacy, Southern University Bangladesh, Mehedibag (Chittagong), Bangladesh
3 Department for Management of Science and Technology Development; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam
4 Department of Pharmacology, School of Medicine, Institute of New Drug Development, Chonbuk National University, Jeonju, South Korea

Correspondence Address:
Mr. Muhammad Torequl Islam
Department for Management of Science and Technology Development and Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City-700000
Vietnam
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ayu.AYU_213_17

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Background: The herb, Commelina paludosa (CP) Blume (Family-Commelinaceae) is medicinally used by the traditional practitioners in Bangladesh. However, there is a lack of scientific evidence on this medicinal herb. Aim and Objectives: This study aimed to evaluate the phytochemical and pharmacological activities of CP (ethanol [ECP], chloroform [CCP] and n-hexane [NHCP] of whole-plant extracts). Materials and Methods: For this antioxidant, antimicrobial, antidiarrheal and antipyretic activities of crude extracts of CP were conducted by 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, disc diffusion and serial dilution, castor oil-induced diarrhea and yeast powder-induced pyrexia methods respectively. Results and Observation: The results suggest that all the fractions significantly scavenged DPPH radicals. In the disc diffusion test, the zones of inhibition were observed within the range of 7 mm to 30.67 mm at 500 mg/disc. The highest zones of inhibition were observed by ECP, CCP and NHCP against Bacillus azotoformans, Lactobacillus coryifomis and Salmonella typhi respectively. NHCP was found to exert stronger antibacterial effect than the ECP and CCP. Conclusion: Minimum inhibitory concentrations were detected within the range of 31.25 and 250 μg/ml. Moreover, the crude fractions also showed significant (P < 0.05) antidiarrheal and antipyretic activities in Swiss mice. CP may be a good source of therapeutic components.


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