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Year : 2014  |  Volume : 35  |  Issue : 1  |  Page : 108-110

Anti-inflammatory activity of Guduchi Ghana (aqueous extract of Tinospora Cordifolia Miers.)


1 Department of Rasa Shastra and Bhaishajya Kalpana including drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
2 Department of Rasa Shastra and Bhaishajya Kalpana, J.S. Ayurved College, Nadiad, Gujarat, India
3 Pharmaceutical Chemistry Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
4 Research and Development, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka, India

Correspondence Address:
Biswajyoti Patgiri
Asso. Prof., Department of Rasashastra and Bhaishjya Kalpana, I.P.G.T. and R.A. Gujarat Ayurved University, Jamnagar - 361 008, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.141958

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Background: Guduchi Ghana is one of the unique Ayuvedic classical preparation which is prepared from aqueous of extract of Guduchi (Tinospora cordifolia Miers.) stem. It is one of the frequently used drugs to treat the Madhumeha, Pandu, Kamala, Amlapitta, Grahani, Kustha, Jirna Jwara and Viswamjwara, Trishna, Shool, Yakritavikara, etc. Looking to these indications, in market most of the Pharma industries prepared Guduchi Ghana by applying the various extraction process. Aim: To evaluate comparative anti-inflammatory activity of classically prepared and market sample of Guduchi Ghana. Materials and Methods: Both samples were evaluated for anti-inflammatory activity using carrageenan induced paw edema model in rats. Animals were divided in three groups, having six animals in each. Group A received test drug, Group B received market sample at a dose of 50 mg/kg orally, while Group C (control group) received tap water. Results: Reduction in edema was observed in Group A and B at 3 h interval by 33.06% and 11.71% respectively. Group A showed significant effects (P < 0.05) in comparison to control group. Conclusion: These experimental results have shown anti-inflammatory activity of Guduchi Ghana.


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