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PHARMACOLOGICAL STUDY
Year : 2013  |  Volume : 34  |  Issue : 4  |  Page : 433-439

Antihyperglycemic and antioxidant activity of Clitorea ternatea Linn. on streptozotocin-induced diabetic rats


1 PG Scholar, Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, India
2 Professor, Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, India
3 PG Scholar, Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra, India
4 Professor and Head, Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon, Pune, Maharashtra, India

Correspondence Address:
Uma A Bhosale
Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune - 411 041, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.127730

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Ethanol extract of Clitorea ternatea Linn. (EECT) was evaluated for its antihyperglycemic and antioxidative activity in normal and streptozotocin-induced diabetic rats. Antihyperglycemic activity of EECT was studied in normal fasted and glucose fed hyperglycemic and epinephrine induced hyperglycemic rats by estimating fasting serum glucose (FSG) by glucose oxidisae or peroxidase enzymatic method. Antioxidant activity of EECT was studied by assaying lipid peroxide/Thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), total nitric oxide, catalase (CAT) and glutathione levels in diabetic rats. The EECT (200 and 400 mg/kg) showed significant antihyperglycemic activity by decreasing FSG in all hyperglycemic models except epinephrine induced hyperglycemic rats; in which improvement in FSG was observed only with EECT in 400 mg/kg dose, whereas significant decrease in TBARS (P < 0.001), nitric oxide (P < 0.001) and significant increase in SOD (P < 0.001), CAT (P < 0.01) and reduced glutathione levels (P < 0.001) was observed in animals treated with EECT (200 and 400 mg/kg) compared to diabetic control group. The results indicated that EECT has remedial effects on hyperglycemia and oxidative stress in diabetic rats.


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