Login   |  Users Online: 658 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Search Article 
  
Advanced search 
   Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts
PHARMACOLOGICAL STUDY
Year : 2013  |  Volume : 34  |  Issue : 3  |  Page : 327-330

Acute toxicity study of Vasaguduchyadi Kwatha: A compound Ayurvedic formulation


1 Lecturer and Head, Department of Pharmacology, Institute of Ayurvedic Pharmaceutical Sciences, Gujarat Ayurved University, Jamnagar, Gujarat, India
2 Drug Discovery Team, Research and Development, The Himalaya Drug Company, Makali, Bangalore, India
3 Head, Pharmaceutical Chemistry Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
4 Professor and Head, Department of Rasa Shastra and Bhaishjya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
5 Director, Reseach and Development, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India

Correspondence Address:
Kalpu N Kotecha
Lecturer and Head, Department of Pharmacology, Institute of Ayurvedic Pharmaceutical Sciences, A. K. Jamal Bldg, Gujarat Ayurved University, Jamnagar, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.123138

Rights and Permissions

Vasaguduchyadi Kwatha is a compound Ayurvedic formulation, indicated for the treatment of liver diseases, especially for Kamala (jaundice) and Panduroga (anemia). However, till date, no safety profile of this formulation has been reported; hence, in the present study, freshly prepared and market samples of Vasaguduchyadi Kwatha were evaluated for acute toxicity. Acute toxicity test was evaluated as per OECD 425 guidelines with 5 000 mg/kg as limit test in Wistar strain albino rats. Test formulations were administered to overnight fasted animals and parameters like body weight, behavioral changes, and mortality were assessed for 14 days. Hematological and biochemical parameters were assessed on 14 th day. Results showed no significant changes in terms of behavioral changes, mortality, and body weight. Both the samples did not affect any of the hematological parameters. However, increase in blood urea level was observed. This study shows that both the samples of Vasaguduchyadi Kwatha are relatively safe up to the dose of 5 g/kg. However, further chronic toxicity evaluation is necessary to establish its safety profile on chronic administration.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1906    
    Printed34    
    Emailed0    
    PDF Downloaded359    
    Comments [Add]    

Recommend this journal