Login   |  Users Online: 955 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Search Article 
  
Advanced search 
   Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts
PHARMACOLOGICAL STUDY
Year : 2013  |  Volume : 34  |  Issue : 3  |  Page : 316-321

Evaluation of antinociceptive effects of Tragia plukenetii: A possible mechanism


1 Professor and Head, Department of Pharmacognosy and Phytochemistry, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Andhra Pradesh, India
2 Research scholar, Department of Pharmacognosy and Phytochemistry, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Andhra Pradesh, India

Correspondence Address:
Sama Venkatesh
Professor and Head, Department of Pharmacognosy and Phytochemistry, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad- 500 028, Andhra Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.123135

Rights and Permissions

Tragia plukenetii R.Smith. (Euphorbiaceae) is an erect, prostate herb with sparsely hispid stinging hairs. In the present study, ethanolic extract and its fractions of T. plukenetii aerial parts were evaluated for antinociceptive and central nervous system (CNS) depressant effects. Among all the extracts, chloroform extract has produced significant analgesic activity at a test dose of 250 mg/kg in acetic acid induced writhing test and Eddy's hotplate test. The analgesic effect of chloroform extract (68.83% inhibition) is comparable with aspirin (72.09% inhibition) in acetic acid induced writhing test. Chloroform extract significantly increased the latency time in hotplate test. In the study of CNS depressant effect, the chloroform extract was found to produce a significant (P < 0.01) reduction of the exploratory capacity and depressant effect in locomotor activity. From the point of CNS depressant and good protective effect on chemical and thermal pain stimuli, indicates that T. plukenetii chloroform extract may have morphinomimetic properties. The naloxone is not able to alter the T. plukenetii induced antinociceptive effect in writhing and hotplate test. Thus, the observed antinociceptive activity of T. plukenetii might have resulted from the activation of peripheral receptors.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1967    
    Printed36    
    Emailed1    
    PDF Downloaded265    
    Comments [Add]    
    Cited by others 3    

Recommend this journal