A comparative toxicological study of Rasamanikya prepared with three different methods
Sushant Sud1, P Sekhar Reddy2, K Sujatha2, Sudheendra Honwad3
1 Assistant Professor, Department of Agadtantra, International Centre for Ayurvedic Studies, Shri Gulab Kunverba Ayurved Mahavidyalaya, Gujarat Ayurved University, Jamnagar, Gujarat, India
2 Associate Professor, Department of Rasashastra, Shri Dharmasthala Manjunatheshwar College of Ayurveda, Udupi, Karnataka, India
3 Assistant Professor, Department of Rasashastra, Shri Dharmasthala Manjunatheshwar College of Ayurveda, Udupi, Karnataka, India
501, Shiva Residency, Rajputpara-3, Limda Lane, Jamnagar, Gujarat
Source of Support: None, Conflict of Interest: None
Rasamanikya a familiar drug, frequently used by Ayurvedic physicians. It also has a high demand in current pharmaceutical industry. Rasamanikya possesses different pharmaceutical methods with many a proved clinical studies. But it is of utmost importance to understand the safety profile of drug based on assurance which could be done by carrying out animal experimentation. In the present study, Rasamanikya was prepared with three methods. The toxicological study was carried out on acute and sub-acute toxicity of the drug. The three samples when compared together showed that Rasamanikya prepared out of classical Abhraka Patra method and modified Sharava Samputa method showed minimal histopathological changes proving its non-toxicity, whereas Rasamanikya prepared out of electric bulb method showed mild toxicity, but with chances of recovery. Acute toxicity study showed no immediate and evident toxic signs and mortality in histopathology reports and liver function test. However, sub-acute toxicity study showed mild to moderate fatty changes in liver.