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PHARMACOLOGICAL STUDY
Year : 2013  |  Volume : 34  |  Issue : 3  |  Page : 302-304

Anti‑inflammatory effect of Chandrashura (Lepidium sativum Linn.) an experimental study


1 Lecturer, Department of Dravyaguna, Government Ayurvedic Collage, Junagadh, Gujarat, India
2 Director, SDM Research Centre for Ayurveda and Allied Sciences, Kuthpady, Udupi, India
3 Drug Discovery Team, Research and Development, The Himalaya Drug Company, Makali, Bangalore, Karnataka, India

Correspondence Address:
Nita D Raval
Patel Colony 2/2, Ashirvad Tenaments, Jamnagar, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.123132

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Lepidium sativum Linn. (Chandrashura) of Family Cruciferae (Brassicaceae) is being used by the people of Gujarat for treating inflammatory condition like arthritis. To evaluate its anti-inflammatory activity, Charles Foster albino rats were selected and experiments were carried out in three groups, therapeutic dose group, twice of therapeutic dose group and control group. In Carrageenan-induced paw oedema, the test drug produced moderate anti-inflammatory activity; however, the effect did not show statistically significant activity due to variation in the data of the control group. In formaldehyde-induced paw oedema in rats, the test drug produced moderate to significant suppression. This indicates that Chandrashura has a strong inhibitory effect on proliferation of fibroblasts and also probably has connective tissue modulation effect.


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