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PHARMACOLOGICAL STUDY
Year : 2013  |  Volume : 34  |  Issue : 2  |  Page : 226-228

Analgesic activity of Nelsonia canescens (Lam.) Spreng.root in albino rats


1 Ph. D. Scholar, Department of Pharmacy, Saurashtra University, Rajkot, Gujarat, India
2 Assistant Professor, Uttaranchal Ayurvedic College, Old Mussoie Road, Rajpur, Dehradun, India
3 Drug Discovery Team, Research and Development, The Himalaya Drug Company, Makali, Bangalore, India
4 Lab technician, Pharmacology lab, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
5 Associate Professor, Department of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
6 Head, Pharmaceutical Chemistry Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

Correspondence Address:
B K Ashok
Drug Discovery Team, R and D, The Himalaya Drug Company, Makali, Bangalore - 562 123
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.119688

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Present study was undertaken to evaluate analgesic activity of root of Nelsonia canescens (Lam.) Spreng, a folklore medicinal plant used as the one of the source plant of Rasna. Study was carried out at two dose levels (270 mg/kg and 540 mg/kg) in albino rats. Analgesic activity was evaluated in formalin induced paw licking, and tail flick methods whereas indomethacin and pentazocine were used as standard analgesic drugs, respectively. At both the dose levels, test drug non-significantly decreased paw licking response at both time intervals. In tail flick model, the administration of the test drug increased pain threshold response in a dose dependent manner. In therapeutically equivalent dose level, analgesic activity was observed only after 180 min while in TED ×2 treated group analgesia was observed at 30 min and lasted even up to 240 min. The results suggested that N.canescens root possess moderate analgesic activity.


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