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PHARMACOLOGICAL STUDY
Year : 2013  |  Volume : 34  |  Issue : 2  |  Page : 220-225

Evaluation of anti-hyperlipidemic activity of Lekhana Basti in albino rats


1 Ph. D. Scholar, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
2 Associate Professor, Department of Panchakarma, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
3 Head, Pharmaceutical Chemistry Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
4 Drug Discovery Laboratory, Himalaya Health Care, Makali, Bangalore, India
5 Director, Research and Development Unit, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India

Correspondence Address:
S Auti Swapnil
B/16, Staff colony, Gujarat Ayurved University, Jamnagar, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.119687

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Lekhana Basti (medicated enema) is a Tikshna formulation which is basically aimed for Apatarpana of the body. The present study (medicated enema) was undertaken to evaluate its anti-hyperlipidemic activity in diet-induced hyperlipidemia animals. Parameters like changes in body weight, organ weight, serum total cholesterol, serum triglyceride, serum HDL cholesterol, and serum (LDL + VLDL) cholesterol were studied to assess the effect of therapy in comparison to the control groups. Lekhana Basti was found to be ineffective in producing anti-hyperlipidemic action potently, but still found to have cytoprotective activity against hyperlipidemia induced organ damage, which was also confirmed by attenuation of cell infiltration and microfatty changes on histopathological examination.


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