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PHARMACOLOGICAL STUDY
Year : 2012  |  Volume : 33  |  Issue : 2  |  Page : 303-306

Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats


1 Senior Research Fellow, National Research Institute of Ayurvedic Drug Development, Central Council for Research in Ayurvedic Sciences, Department of AYUSH, Ministry of Health and Family Welfare, Government of India, Kolkata, West Bengal, India
2 Assistant Director, Department of Pharmacology, National Research Institute of Ayurvedic Drug Development, Central Council for Research in Ayurvedic Sciences, Department of AYUSH, Ministry of Health and Family Welfare, Government of India, Kolkata, West Bengal, India
3 Research Officer, (Ayurveda), National Research Institute of Ayurvedic Drug Development, Central Council for Research in Ayurvedic Sciences, Department of AYUSH, Ministry of Health and Family Welfare, Government of India, Kolkata, West Bengal, India
4 Director, National Research Institute of Ayurvedic Drug Development, Central Council for Research in Ayurvedic Sciences, Department of AYUSH, Ministry of Health and Family Welfare, Government of India, Kolkata, West Bengal, India

Correspondence Address:
Sachhidananda Upadhyay
Department of Pharmacology, National Research Institute of Ayurvedic Drug Development, 4 CN Block, Sector V, Bidhannagar, Kolkata - 700 091, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.105257

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The present study was carried out to assess the safety of standardized Panchakola Avaleha on albino rats (Wistar strain). Animals were administered three doses of Panchakola Avaleha by oral routes, viz. higher (500 mg/kg/day), middle (250 mg/kg/day), and therapeutic dose (50 mg/ kg/ day) for 28 consecutive days. Effects of the test drug on hematological, biochemical, and histopathologic parameters were evaluated. This study revealed normal behavior, no mortality, and no significant changes in hematological, biochemical, and histopathological examinations.


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