Login   |  Users Online: 1050 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Search Article 
  
Advanced search 
   Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts
PHARMACOLOGICAL STUDY
Year : 2012  |  Volume : 33  |  Issue : 2  |  Page : 299-302

In vitro antimicrobial and brine shrimp lethality of Allophylus cobbe L.


1 Lecturer, Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, Chittagong, Bangladesh
2 M. Pharm. Scholar, Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, Chittagong, Bangladesh
3 Professor, Department of Biochemistry and Pharmacology -CCS-UFPI, Post Graduate Program in Pharmaceutical Sciences, Campus Minister Portella - Bairro ining, Teresina, Brazil

Correspondence Address:
Md. Torequl Islam
Department of Pharmacy, Faculty of Science and Engineering, Southern University Bangladesh, Shaheed Mirza Lane (East), Mehedibag Road, Chittagong
Bangladesh
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.105256

Rights and Permissions

Plants are rich source of pharmacologically active agents, which could be explored in disease management. Methanol, ethanol, and petroleum ether extracts of the whole plant of Allophylus cobbe L. were evaluated for antimicrobial and cytotoxic activities. In vitro antimicrobial sensitivity by disk diffusion method was conducted against four Gram-positive and seven Gram-negative pathogenic bacteria and seven fungi. In the antibacterial and antifungal sensitivity tests, growth inhibition was found to be within the range of 10.0-17.67 mm. Strong zone of inhibition by the ethanol extract of A. cobbe (EEAC) was found against Trichophyton spp. With some exceptions, a mild to strong antimicrobial activity was observed in this study. Significant minimum inhibitory concentration (MIC; 15.625 μg/ml) was found against Trichophyton spp. Other detected MICs were within the range of 31.25-125 μg/ml. The petroleum ether extract of the plant exhibited strong cytotoxicity in the brine shrimp lethality bioassay test.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1621    
    Printed57    
    Emailed0    
    PDF Downloaded307    
    Comments [Add]    

Recommend this journal