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PHARMACOLOGICAL RESEARCH
Year : 2012  |  Volume : 33  |  Issue : 1  |  Page : 123-129

In vitro antibacterial and antifungal activities of Cassia fistula Linn. fruit pulp extracts


1 Research Associate, ADL, Zydus Cadila Healthcare, Ahmedabad, India
2 Research Scientist, ADL, Ramniklal Manikchand Dhariwal Research Centre, Valsad, India
3 Associate Professor, Department of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
4 Head, Pharmaceutical Chemistry Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

Correspondence Address:
N R Bhalodia
Panchavati Gaushala, 95-B, Saru Section Road, Opposite Gita Bungalow, Jamnagar, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.100329

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Aim of the study is to assess the antimicrobial activity Cassia fistula fruit pulp extracts on some bacterial and fungal strains. Hydro alcohol and chloroform extracts of Cassia fistula fruit pulp were evaluated for the potential antimicrobial activity. The antimicrobial activity was determined in both the extracts using the agar disc diffusion method. Extracts were effective on tested microorganisms. The antibacterial and antifungal activities of solvent extracts (5, 25, 50, 100, 250 μg/mL) of C. fistula were tested against two gram positive, two gram negative human pathogenic bacteria and three fungi, respectively. Crude extracts of C. fistula exhibited moderate to strong activity against most of the bacteria tested. The tested bacterial strains were Staphylococcus aureus, Streptococcus pyogenes, Escherichia coil, Pseudomonas aeruginosa, and fungal strains were Aspergillus. niger, Aspergillus. clavatus, Candida albicans. The antibacterial potential of the extracts were found to be dose dependent. The antibacterial activities of the C. fistula were due to the presence of various secondary metabolites. Hence, these plants can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals research activities.


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