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PHARMACOLOGICAL RESEARCH
Year : 2011  |  Volume : 32  |  Issue : 4  |  Page : 576-584

Antiobesity effect of Stellaria media against drug induced obesity in Swiss albino mice


1 Associate Professor and Head, Department of Pharmacology, CMR College of Pharmacy, Medchal, Hyderabad, Andhra Pradesh, India
2 Principal, SAL Institute of Pharmacy, Ahmedabad, India
3 Head, Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India
4 Assistant Professor, Department of Pharmacology, Sudhakarrao Naik Institute of Pharmacy, Pusad, Maharashtra, India
5 PhD Scholar, London Metropolitan University, London, United Kingdom

Correspondence Address:
Vijay R Chidrawar
Associate Professor and Head, Department of Pharmacology, CMR College of Pharmacy, Nizamabad Road, Medchal, Hyderabad, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-8520.96137

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The whole plant of Stellaria media (family: Caryophyllaceae) has been tested for its antiobesity activity by using progesterone-induced obesity model in female albino mice. The effect of S. media on food consumption pattern, change in body weight, thermogenesis, lipid metabolism, and histology of fat pad. were examined. Methanolic and alcoholic extracts of the S. media were used in the study. Methanolic extract of S. media (MESM) have prevented the increase in body weight, adipose tissue weight and size, and upturned obesity and associated complications. MESM has also shown promising effects compared with alcoholic extract of S. media may be because of its multiple mechanisms. These findings suggest that antiobesity activity produced by MESM is because of its anorexic property mediated by saponin and flavonoid and partly of by its β-sitosterol content. β-Sitosterol in the plant extract was confirmed by thin-layer chromatography study. β-sitosterol is plant sterol having structural similarity with dietary fat which do the physical competition in the gastrointestinal tract and reduces fat absorption. Before carrying in vivo activity detail pharmacognostic and phytochemical analysis of the extracts was carried out. The plant has shown the presence of saponin, flavonoids, steroids and triterpenoids, glycosides, and anthocynidine. By this study, it can be concluded that, MESM is beneficial in suppression of obesity induced by progesterone.


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