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RESEARCH ARTICLE
Year : 2009  |  Volume : 30  |  Issue : 4  |  Page : 484-488

Anti ulcer activity of Narikela Khanda & Narikela Khanda granules


1 Lecturer, Dept. of R.S. & B.K., B.N.M.R. Ayurvedic Medical College and Research Center, Bijapur - 586101 (Karnataka), India
2 S.R.F. (CCRAS), Pharmacology Laboratory, I.P.G.T.&R.A., Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
3 Reader, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
4 Professor and H.O.D., Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
5 Head, Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
Pramod C Baragi
Lecturer, Dept. of R.S. & B.K., B.N.M.R. Ayurvedic Medical College and Research Center, Bijapur - 586101 (Karnataka)
India
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Source of Support: None, Conflict of Interest: None


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Today in the modern era, gastric disorders like hyperacidity and gastric ulcers are a common clinical entity. This is also a major health problem with multifunctional etiology. Today there is need for a potent herbal formulation which can cure hyperacidity and ulcers. The present comparative experimental study was planned to see the anti ulcer activity of herbal compound formulations of Narikela Khanda and Narikela Khanda granules using pyloric ligation induced gastric ulceration in rats.Gastric ulcers were induced in albino rats by pyloric ligation. Effects of both the test formulations on different parameters in gastric juice like volume, pH, total and free acids, peptic activity, total carbohydrate (TC), total protein (TP) and also gastric mucosal damage were assessed. Both the formulations did not produce significant effect on gastric juice volume, free acidity, total protein, total carbohydrate, TC:TP ratio and ulcer index, however Narikela Khanda granules produced significant increase of gastric juice pH and significant decrease in total acidity and peptic activity. The study clearly indicates that Narikela Khanda possesses weak anti-ulcer activity, while Narikela Khanda granules possess moderate anti-ulcer activity against pyloric ligation induced gastric ulcers.


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