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RESEARCH ARTICLE
Year : 2009  |  Volume : 30  |  Issue : 1  |  Page : 55-61

An Experimental evaluation on Nephroprotective activity of Nagaradi Kashaya


1 Ph.D. Scholar, P. G. Deptt. of Shalya, National Institute of Ayurveda, Jaipur, India
2 Head, Deptt. of Shalya Tantra, National Institute of Ayurveda, Jaipur, India
3 Reader in Shalakya, I.P.G.T. & R.A., Gujarat Ayurved University, Jamnagar, India
4 Head - Pharmacology laboratory, I.P.G.T. & R.A., Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
Mukesh Kumar Meena
Ph.D. Scholar, P. G. Deptt. of Shalya, National Institute of Ayurveda, Jaipur
India
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Source of Support: None, Conflict of Interest: None


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Kidneys are among the highly vascularised organs receiving around 20-25% of the cardiac output. Because of this reason they are constantly exposed to xenobiotics including environmental pollutants, many a times leading to impairment and damage to the kidney. In such a situation, availability of nephroprotective drugs would serve very important therapeutic purpose. In Ayurveda several drugs are used as nephroprotectives and this group of drugs acts as good non-specific cytoprotectives. In this context ayurvedic classical formulations, Ashmarihar kashaya (Siddha yoga samgraha chap. 18) and Nagaradi kashaya (Chakradatta chap. 28) were studied as nephroprotective agents in the present experimental study on Albino rats. The results were assessed by using a battery of parameters i.e. serum biochemical parameters, biochemical parameters in kidney homogenate and histopathological study of the kidney and heart. It was observed that the gentamicin and cisplatin induced nephropathy was mild to moderately antagonized by using Ashmarihara kashaya; while, no antagonism of nephropathy was noticed in Nagaradi kashaya as nephroprotective agents. Surprisingly, it was seen that, both drugs produce mild to moderate cardioprotective effect against gentamicin and cisplatin induced cardio-toxicity.


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