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RESEARCH ARTICLE
Year : 2008  |  Volume : 29  |  Issue : 4  |  Page : 231-234

A Comparative Study on Vrikka Samrakshanatmaka and Ashmarighna Effect of Tiladi Kshara and Varunadi Ghrita (Nephroprotective and Lithotripsic effect)


1 R.M.O., Instt. of P. G. Ayurvedic Education & Research, Shyamadas Vaidya Shastra Peeth, Kolkata, India
2 HOD - Basic Principles & Ex-I/c Director, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
3 Reader in Shalakya Tantra, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
4 Head - Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
Asim Kumar Mandal
R.M.O., Instt. of P. G. Ayurvedic Education & Research, Shyamadas Vaidya Shastra Peeth, Kolkata
India
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Source of Support: None, Conflict of Interest: None


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The kidneys play a very important role in the maintenance of homeostasis in the body. They perform several important functions like normal fluid and acid base balance, electrolyte balance, production and secretion of hormones and excretion of metabolic products. Kidneys are highly vascularized organs receiving around 20-25% of the cardiac output, because of this reason they are constantly exposed to xenobiotics including environmental pollutants, and hence are on the risk of nephrotoxicity. In Ayurveda several drugs are used as nephroprotectives, in this study the well known Ayurvedic compound formulations ' Varunadi Ghrita' and 'Tiladi Kshara' were used to evaluate the nephroprotective effect against gentamycin induced nephrotoxicity. Total 36 animals in 6 groups were taken and weighed. Test drugs and vehicles were administered to respective groups, after two hours, Gentamycin (60 mg./kg. I.P) was administered to all groups except water control group for 15 consecutive days. On 16th day animals were weighed again and sacrificed by cervical dislocation and severing the jugular veins. Blood samples and kidneys were collected for estimation of serum biochemical investigations and histopathological studies respectively. Accurately weighed kidney tissues were also taken and homogenate was prepared for the estimation of different biochemical investigations. The result in the context of the objective of the study emerges that Varunadi Ghrita possess moderate nephroprotective activity. However, the study could not provide basis for its relevance to the probable efficacy of the test drug in kidney stone induced nephropathy.


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