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RESEARCH ARTICLE
Year : 2008  |  Volume : 29  |  Issue : 2  |  Page : 77-83

Psycho-Pharmacological study on Antidepressant and Anxiolytic Effect of Brahmi Ghrita


1 M.D. (Ayu.) - Mano Vijnana Evam Manas Roga, Deptt. of Panchakarma & Manas Roga, I.P.G.T. & R.A., Gujarat Ayurved University, Jamnagar, India
2 Senior Research Fellow -Pharmacological Research Unit, CCRAS, I.P.G.T. & R.A., Gujarat Ayurved University, Jamnagar, India
3 Lecturer, PGT-SFC-CELL, I.P.G.T. & R.A., Gujarat Ayurved University, Jamnagar, India
4 Head-Pharmacology Lab., I.P.G.T. & R.A., Gujarat Ayurved University, Jamnagar, India
5 Professor of Kayachikitsa & Dean - I.P.G.T. & R.A., Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
Yogesh S Deole
M.D. (Ayu.) - Mano Vijnana Evam Manas Roga, Deptt. of Panchakarma & Manas Roga, I.P.G.T. & R.A., Gujarat Ayurved University, Jamnagar
India
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Source of Support: None, Conflict of Interest: None


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This research is carried out with the aim to study anti depressant and anxiolytic effect of Brahmi ghrita, which comprises Brahmi (Bacopa monnieri Linn),Vacha (Acorus calamus Linn),Shankhapushpi (Convolvulus pluricaulis Chois) and Kushtha (Saussurea lappa C.B.Clarke) processed in cow's ghee. Brahmi, which is the main ingredient of the formulation, is proven for its Tranquilizing, Smooth muscle relaxant, Nootropic, Nerve tonic, Adoptogenic, Anti stress, Anxiolytic, Anti depressant, Memory booster, learning facilitator effects. Vacha has sedative, analgesic and tranquilizing effects. Kushtha shows anticytotoxic, diuretic, hypolipidemic, hypotensive, spasmolytic, immunostimulant activity. Shankhapushpi has spasmolytic, hypotensive, sedative, anti inflammatory, antistress, anti anxiety effects. Considering these activities, Brahmi ghrita is studied on experimental models such as Gross behaviour test, Anti depressant test and Anti anxiety test on Swiss Albino mice of either sex. The trial drug showed mild hyperactivity in gross behaviour and dose dependent mild anxiolytic effect in open field behaviour and Elevated plus maze test. Dose dependent variation in effect of Brahmi ghrita is observed in behaviour despair test, as it is mild stimulant at lower dose and depressant at higher dose. It showed significant potentiation of L-DOPA activity in comparison to water control, but the effect was insignificant in comparison to ghrita control. Thus it showed complex nature of pharmacological activity.


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