Login   |  Users Online: 1453 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Search Article 
  
Advanced search 
   Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts
RESEARCH ARTICLE
Year : 2007  |  Volume : 28  |  Issue : 3  |  Page : 68-76

A Comparative Psycho-Neuro-Pharmacological Study on Guduchyadi Ghrita & Bhringarajadi Ghrita Rasayana


1 Lecturer in Yogic Science, Morarji Desai Instt. Of Naturopathy & Yogic Science, Vadodara, Gujarat, India
2 Lecturer PGT- SFC-CELL, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
3 Head- Pharmacology Lab, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
4 Professor of Kayachikitsa, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
Devangi N Shukla
Lecturer in Yogic Science, Morarji Desai Instt. Of Naturopathy & Yogic Science, Vadodara, Gujarat
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

This study has been carried out to compare the Psycho-neuro-pharmacological basis for the use of Guduchyadi Ghrita and Bhringarajadi Ghrita. Guduchyadi Ghrita Rasayana consisting of Guduchi (Tinospora cordifolia Linn), Apamarga (Achyrenthus aspera Linn), Vidanga (Embelia ribes Burm. F.), Shankhapushpi (Convolvulus pluricaulis Chois), Vacha (Acorus calamus Linn), Haritaki (Terminalia chebula Retz), Kushtha (Saussurea lappa C.B.Clarke ) and Shatavari (Asparagus racemosus Willd), has proven mental health promoting, memory enhancing, anti-stress, anti- depressant properties that may slow down the Aging process by counteracting stress. Bhringarajadi Rasayana consisting of Bhringaraja (Eclipta alba Hassk.), Krishna Tila (Sesamum orientale Linn.), Amalaki (Embelica officinalis Gaertn.), Mishri (Sugar) with proven adaptogenic, antioxidant, free radicals scavenger, immuno-modulator properties play a major role in the management of Aging process. Both the formulations are supposed to possess CNS activity, Anti-stress, adaptogenic and other pharmacological activities. Based on this promise the test Ghrita had been studied on various experimental models such as Gross behaviour test, Anti depressant test, Anti-anxiety test and Antistress adaptogenic test on Swiss Albino Mice and Charles Foster strain albino rats of either sex. On Gross behaviour study, both the test drugs showed hypoactivity. In the Anti depressant activity, Guduchyadi Ghrita showed significant decrease in the Mice Behavioral "despair" test, moderate decrease in Mice immobility in Chronic fatigue syndrome test and produced potentiation of L dopa effects. Bhringarajadi Ghrita showed no discernible Anti depressant and Chronic fatigue syndrome test though moderate potentiation of L dopa effect was observed. Guduchyadi Ghrita also produces antianxiety activity and Adaptogenic activity. None of the formulation was able to reverse stress induced Hypothermia. Slightly higher decrease in stress induced ulceration was observed with Guduchyadi Ghrita, however Bhringarajadi Ghrita had no effect. No statistically significant effect observed on Haematological, Biochemical parameter and DHEA-S (Dehydroepiandrosterone Sulfate). Guduchayadi Ghrita showed marginal elevation of DHEA-S level.


[PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1310    
    Printed96    
    Emailed2    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal