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RESEARCH ARTICLE
Year : 2007  |  Volume : 28  |  Issue : 1  |  Page : 17-22

A Pharmacological Study on Hypnotic Activity of Mamsyadi Ghrita


1 M. D. (Ayu) Scholar, Manasaroga Evam Manovigyan, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
2 Head- Pharmacology Lab., Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
3 Professor of Kayachikitsa, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
Anil Kumar Singh
M. D. (Ayu) Scholar, Manasaroga Evam Manovigyan, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar
India
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Source of Support: None, Conflict of Interest: None


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This study has been carried out to find out whether pharmacological basis exist for the use of Mamsyadi Ghrita- sleep promoting formulation consisting of Nardostachys Jatamansi, Convolvulus pluricaulis, Withania somnifera and Valeriana jatamansi in equal ratio. Sleep promoting drugs are supposed to posses CNS depression activity and majority of such depressants normally possess anti-anxiety activity. Based on this premise the test ghrita has been studied on various experimental models such as Gross behaviour test, Open field behaviour test and Plus maze test etc. On Swiss albino mice. Gross Behaviour Study, Mamsyadi Ghrita showed mild hypoactivity. In Elevated Plus Maze Test, the drug produced significant decrease in the duration spent in open tunnel indicating pro-anxiety activity. In the Open Field Apparatus Study, Mamsyadi Ghrita showed no effect on number of squares crossed. On Hypnotic Potentiation Test, the present study showed nonsignificant but moderate prolongation.


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