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RESEARCH ARTICLE
Year : 2006  |  Volume : 27  |  Issue : 3  |  Page : 67-74

A Comparative Pharmaco - Clinical Study on Anti-Asthmatic Effect of Shirisharishta Prepared by Bark, Sapwood and Heartwood of Albizia Lebbeck


1 M.D. (Ayu.) Scholar, Dept. of R.S. & B.K., Institute for Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
2 Reader & Head, Dept. of R.S. & B. K., Institute for Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
3 Lecturer, Dept. of R.S. & B. K., Institute for Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
4 Head, Pharmacology Lab., Institute for Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
Mundeep Jaiswal
M.D. (Ayu.) Scholar, Dept. of R.S. & B.K., Institute for Post Graduate Teaching & Research in Ayurveda, Gujarat Ayurved University, Jamnagar
India
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Source of Support: None, Conflict of Interest: None


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Shirisharishta is a compound formulation having main content as Shirisha. Shirisha (Albizia lebbeck Benth.) is a well known classical drug for the treatment of various types of diseases such as Shwasa, Kasa etc. The plant is reported to have various pharmacological properties like anti-asthmatic, antihistaminic, anti-protozoal etc. Most of the recent studies are reported about the pharmacological actions of it's bark, leaves, pods and fruits, but almost negligible references about the pharmacological action of it' heartwood are available. Nowadays Twak (bark) is commonly used for the preparation of Shirisharishta, but Sara (heartwood) is the part which is indicated in Asava Yoni. Shwasa Roga (Asthma) is one of the most common chronic diseases in the world. It may be defined as a disease in which the respiration is disturbed due to narrowing or obstruction in the channels. Bronchial asthma is a common disease affecting 10% to 20% of population. Considering the above facts in the present study Shirisharishta was prepared by Twaka (bark), Kastha (sapwood) and Sara (heartwood) of Shirisha. Pharmacologically Shirisharishta prepared by Sara shows significant result in anti-inflammatory and anti-tussive actions and significant increase in anti-histaminic activity while better activity profile in CMI suppression activity than the other two groups of Arishta. Clinical study on 41 patients also supports the experimental data in which Shirisharishta prepared by Sara shows better result in curing the disease Shwasa (Asthma).


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