Login   |  Users Online: 1226 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
Search Article 
  
Advanced search 
   Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts
RESEARCH ARTICLE
Year : 2006  |  Volume : 27  |  Issue : 3  |  Page : 55-62

A Toxicity Study of Makaradhwaja Prepared by Astasamskarita Parada


1 Lecturer, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
2 Reader & Head, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India
3 Head, Pharmacology laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India

Correspondence Address:
B J Patgiri
Lecturer, Dept. of Rasashastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Makaradhwaja is a well known Ayurvedic medicine prepared by Kupipakwa method. It is prepared by using shuddha Swarna (Gold), Astasamskarita Parada (Mercury) and shuddha Gandhaka (Sulphur) in the ratio of 1:8:16 as ingredients. The present study was under taken to ascertain the safety aspect of the drug through acute and chronic toxicity studies. Acute toxicity study was carried out in Swiss albino mice and chronic toxicity study was carried out in Charles Foster albino rats at different dose levels. The parameters studied were ponderal, haematological, biochemical and histopathological. in case of chronic toxicity study, mortality and behaviour change in acute toxicity. In acute toxicity study the test drug did not produce mortality up to the dose of 480 mg kg-1 (orally) in mice. The result or data obtained during the study indicate no significant changes observed in hematological, biochemical and histopathological parameters except of mild increase in blood sugar level and mild fatty changes in liver.


[PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1304    
    Printed97    
    Emailed3    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal